Millanta F, Andreani G, Rocchigiani G, Lorenzi D, Poli A
Department of Veterinary Sciences, University of Pisa, Italy.
Department of Veterinary Sciences, University of Pisa, Italy.
J Comp Pathol. 2016 May;154(4):297-303. doi: 10.1016/j.jcpa.2016.02.005. Epub 2016 Mar 21.
Overexpression of cyclo-oxygenase (COX)-2 is involved in tumour growth and spread by modulating the production of angiogenic factors such as vascular endothelial growth factor (VEGF). Expression of COX-2 and VEGF was investigated immunohistochemically in 51 canine and feline cutaneous and non-cutaneous squamous cell carcinomas (SCCs) and the correlation between expression of these molecules and clinicopathological variables was evaluated. COX-2 and VEGF expression was not observed in normal skin keratinocytes. COX-2 overexpression occurred in 53% and 61% of the canine and feline SCCs, respectively. The expression of both markers was higher in cutaneous compared with non-cutaneous SCCs. In both species COX-2 and VEGF expression was correlated with the progression of the disease, but not with the presence of lymphatic invasion, tumour grading or tumour classification in the cutaneous tumours. Further study will be required to understand the role of the COX-2 pathway in angiogenesis in SCC.
环氧化酶（COX）-2的过表达通过调节血管生成因子如血管内皮生长因子（VEGF）的产生参与肿瘤的生长和扩散。采用免疫组织化学方法研究了51例犬猫皮肤及非皮肤鳞状细胞癌（SCC）中COX-2和VEGF的表达情况，并评估了这些分子表达与临床病理变量之间的相关性。在正常皮肤角质形成细胞中未观察到COX-2和VEGF表达。COX-2过表达分别出现在53%的犬SCC和61%的猫SCC中。与非皮肤SCC相比，两种标志物在皮肤SCC中的表达更高。在两个物种中，COX-2和VEGF表达均与疾病进展相关，但与皮肤肿瘤中的淋巴管浸润、肿瘤分级或肿瘤分类无关。需要进一步研究以了解COX-2途径在SCC血管生成中的作用。
