Nam Kyung Jin, Choo Ki Seok, Jeon Ung Bae, Kim Tae Un, Hwang Jae-Yeon, Yeom Jeong A, Jeong Hee Seok, Choi Yoon Young, Kim Jin You, Lee Sang Hyup, Kim Hyun Yul, Jung Youn Joo, Cho Young Hye
Department of Radiology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, 20, Geumo-ro, Mulgeum-eup, Yangsan-si, Gyungnam, 626-770, Korea.
Department of Radiology, Pusan National University Hospital, Pusan National University School of Medicine, 179 Gudeok-ro, Seo-gu, Busan-si, 602-739, Korea.
Jpn J Radiol. 2016 Jun;34(6):409-13. doi: 10.1007/s11604-016-0537-3. Epub 2016 Mar 24.
We compared maximal diameters of ipsilateral (IMA) and contralateral (IMA) internal mammary arteries in patients with unilateral breast cancer and analyze the implications of enlargements of ipsilateral or contralateral IMAs in relation to histopathologic factors.
Of 568 women who underwent breast magnetic resonance imaging (MRI) examinations from January 2009 to May 2012, 196 had unilateral, histologically proven breast cancer. In 156 women, maximal IMA diameters in the second intercostal space were measured by two blinded radiologists in left and right sides using nonenhanced axial T2-weighted turbo spin-echo sequence images.
In the 156 study patients, mean maximal diameter of ipsilateral IMAs (2.37 ± 0.60 mm) was significantly larger than that of contralateral IMAs (2.03 ± 0.58 mm) (p = 0.00). Ipsilateral IMA enlargement was present in 66.7 % of the patients (104 of 156). Furthermore, ipsilateral IMA enlargement was found to be significantly associated with human epidermal growth factor receptor-2 (HER-2) expression (p = 0.039).
Maximal IMA diameter was significantly greater in ipsilateral sides in breast cancer patients. Findings suggest ipsilateral IMA enlargement detected by MRI might be a useful additional predictor of HER-2 expression in unilateral breast cancer.
我们比较了单侧乳腺癌患者同侧（IMA）和对侧（IMA）内乳动脉的最大直径，并分析同侧或对侧IMA增粗与组织病理学因素的关系。
在2009年1月至2012年5月接受乳腺磁共振成像（MRI）检查的568名女性中，196名患有单侧经组织学证实的乳腺癌。在156名女性中，两名盲法放射科医生使用非增强轴向T2加权快速自旋回波序列图像测量了第二肋间间隙的IMA最大直径，测量部位为左右两侧。
在156名研究患者中，同侧IMA的平均最大直径（2.37±0.60mm）显著大于对侧IMA（2.03±0.58mm）（p = 0.00）。66.7%的患者（156名中的104名）存在同侧IMA增粗。此外，发现同侧IMA增粗与人类表皮生长因子受体2（HER-2）表达显著相关（p = 0.039）。
乳腺癌患者同侧IMA的最大直径显著更大。研究结果表明，MRI检测到的同侧IMA增粗可能是单侧乳腺癌中HER-2表达的一个有用的额外预测指标。
