Mossello Enrico, Profili Francesco, Di Bari Mauro, Bandinelli Stefania, Razzanelli Matilde, Salvioni Anna, Corridori Carla, Di Fiandra Teresa, Francesconi Paolo
Research Unit of Medicine of Ageing, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Osservatorio di Epidemiologia, Agenzia Regionale di Sanità della Toscana, Florence, Italy.
Age Ageing. 2016 Jul;45(4):469-74. doi: 10.1093/ageing/afw048. Epub 2016 Mar 23.
identification of older individuals at risk for health-related adverse outcomes (HRAO) is necessary for population-based preventive interventions. Aim of this study was to improve a previously validated postal screening questionnaire for frailty in non-disabled older subjects and to test its prognostic validity in a vast sample of older community-dwellers.
individuals aged 70+ underwent a mass postal screening. Physical frailty phenotype (PFP) was assessed in the unselected subsample of the first responders. After a 1-year follow-up, HRAO were recorded in the whole sample, including survival, access to Emergency Department, hospitalisation and Long-Term Care admission.
the questionnaire was mailed to 17,273 subjects, whose response rate was 55%. Among the first 1,037 responders without overt disability, the revised questionnaire was 75% sensitive and 69% specific for PFP (ROC 0.772). Non-disabled subjects who screened positive had a higher risk of HRAO in comparison with those who screened negative and similar to non-responders. Risk of adverse outcome was highest among disabled subjects.
a simple questionnaire delivered by mail has good accuracy in detecting PFP in non-disabled older subjects and is able to predict HRAO.
识别有健康相关不良结局（HRAO）风险的老年人对于基于人群的预防性干预措施至关重要。本研究的目的是改进先前验证的用于非残疾老年人衰弱的邮政筛查问卷，并在大量老年社区居民样本中测试其预后效度。
70岁及以上的个体接受了大规模邮政筛查。在首批应答者的未筛选子样本中评估身体衰弱表型（PFP）。经过1年的随访，在整个样本中记录HRAO，包括生存、急诊就诊、住院和长期护理入院情况。
问卷被邮寄给17273名受试者，应答率为55%。在首批1037名无明显残疾的应答者中，修订后的问卷对PFP的敏感性为75%，特异性为69%（ROC 0.772）。与筛查阴性的受试者相比，筛查阳性的非残疾受试者发生HRAO的风险更高，且与未应答者相似。残疾受试者中不良结局的风险最高。
通过邮件发放的简单问卷在检测非残疾老年人的PFP方面具有良好的准确性，并且能够预测HRAO。
