Dai Yang, Shuai Xiao, Kuang Pu, Wang Lin, Liu Ting, Niu Ting
Department of Hematology and Research Laboratory of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Department of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Oncol Lett. 2017 Mar;13(3):1189-1193. doi: 10.3892/ol.2017.5578. Epub 2017 Jan 10.
Philadelphia chromosome with acute myeloid leukemia (Ph + AML) arising from t(9;22) is an uncommon occurrence. Ph + AML is known to respond poorly to conventional chemotherapy. To the best of our knowledge, simultaneous diagnosis of Ph + AML and lymphoma in a single patient has not yet been reported. The present study reports the case of a 37-year-old female patient who presented with bone pain, fever and lymphadenopathy, and was diagnosed as Ph + AML with concurrent diffuse large B cell lymphoma. Combined chemotherapy regimen covering AML and lymphoma was administered, achieving short-term response. However, the therapy soon failed and the patient succumbed to the disease. The present study reports the first case of Ph + AML occurring concurrently with diffuse large B cell lymphoma, and discusses certain differences between Ph + AML and chronic myelogenous leukemia in the myeloid blast crisis phase, as well as the appropriate therapeutic modalities for Ph + AML. In addition, the potential association between Ph + AML and diffuse large B cell lymphoma in this patient was investigated.
由t(9;22)引起的伴有急性髓系白血病的费城染色体（Ph + AML）并不常见。已知Ph + AML对传统化疗反应不佳。据我们所知，尚未有关于一名患者同时诊断出Ph + AML和淋巴瘤的报道。本研究报告了一名37岁女性患者的病例，该患者出现骨痛、发热和淋巴结病，被诊断为Ph + AML并发弥漫性大B细胞淋巴瘤。给予了涵盖AML和淋巴瘤的联合化疗方案，取得了短期缓解。然而，治疗很快失败，患者最终死于该疾病。本研究报告了首例Ph + AML与弥漫性大B细胞淋巴瘤同时发生的病例，并讨论了Ph + AML与处于髓系母细胞危象期的慢性髓性白血病之间的某些差异，以及Ph + AML的适当治疗方式。此外，还研究了该患者中Ph + AML与弥漫性大B细胞淋巴瘤之间的潜在关联。
