Nardy Ana Flávia Fernandes Ribas, Freire-de-Lima Leonardo, Freire-de-Lima Célio Geraldo, Morrot Alexandre
Instituto de Microbiologia, Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.
Laboratório de Glicobiologia, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.
Front Oncol. 2016 Mar 9;6:54. doi: 10.3389/fonc.2016.00054. eCollection 2016.
Glycans are part of the essential components of a cell. These compounds play a fundamental role in several physiopathological processes, including cell differentiation, adhesion, motility, signal transduction, host-pathogen interactions, tumor cell invasion, and metastasis development. Glycans are also able to exert control over the changes in tumor immunogenecity, interfering with tumor editing events and leading to immune-resistant cancer cells. The involvement of glycans in cancer progression is related to glycosylation alterations. Understanding such changes is, therefore, extremely useful to set the stage for their use as biomarkers, improving the diagnostics and therapeutic strategies. Herein, we discuss the basis of how modifications in glycosylation patterns may contribute to cancer genesis and progression as well as their importance in oncology field.
聚糖是细胞重要组成部分。这些化合物在多个生理病理过程中发挥着基础性作用，包括细胞分化、黏附、运动、信号转导、宿主-病原体相互作用、肿瘤细胞侵袭和转移发展。聚糖还能够控制肿瘤免疫原性的变化，干扰肿瘤编辑事件并导致免疫抗性癌细胞。聚糖参与癌症进展与糖基化改变有关。因此，了解这些变化对于将其用作生物标志物、改进诊断和治疗策略极为有用。在此，我们讨论糖基化模式的改变如何促进癌症发生和进展的基础及其在肿瘤学领域的重要性。
