Schirò Giuseppe, Iacono Salvatore, Ragonese Paolo, Aridon Paolo, Salemi Giuseppe, Balistreri Carmela Rita
Unit of Neurology, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Palermo, Italy.
Cellular and Molecular Laboratory, Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), University of Palermo, Palermo, Italy.
Front Neurol. 2022 Jul 12;13:917527. doi: 10.3389/fneur.2022.917527. eCollection 2022.
The growing incidence of neurodegenerative disorders in our populations is leading the research to identify potential biomarkers and targets for facilitating their early management and treatments. Biomarkers represent the crucial indicators of both physiological and pathological processes. Specific changes in molecular and cellular mechanisms of physiological processes result in biochemical alterations at systemic level, which can give us comprehensive information regarding the nature of any disease. In addition, any disease biomarker should be specific and reliable, able to consent of distinguishing the physiological condition of a tissue, organ, or system from disease, and be diverse among the various diseases, or subgroups or phenotypes of them. Accordingly, biomarkers can predict chances for diseases, facilitate their early diagnosis, and set guidelines for the development of new therapies for treating diseases and disease-making process. Here, we focus our attention on brain neurotrophic factor (BDNF)-tropomyosin receptor kinase (Trk) pathway, describing its multiple roles in the maintenance of central nervous system (CNS) health, as well as its implication in the pathogenesis of multiple sclerosis (MS). In addition, we also evidence the features of such pathway, which make of it a potential MS biomarker and therapeutic target.
人群中神经退行性疾病发病率的不断上升，促使研究人员寻找潜在的生物标志物和靶点，以促进对这些疾病的早期管理和治疗。生物标志物是生理和病理过程的关键指标。生理过程的分子和细胞机制发生特定变化，会导致全身水平的生化改变，这能为我们提供有关任何疾病本质的全面信息。此外，任何疾病生物标志物都应具有特异性和可靠性，能够区分组织、器官或系统的生理状态与疾病状态，并且在各种疾病及其不同亚组或表型之间存在差异。因此，生物标志物可以预测疾病发生的可能性，有助于早期诊断，并为开发治疗疾病及致病过程的新疗法提供指导。在此，我们将注意力集中在脑源性神经营养因子（BDNF）-原肌球蛋白受体激酶（Trk）信号通路，描述其在维持中枢神经系统（CNS）健康中的多种作用，以及其在多发性硬化症（MS）发病机制中的作用。此外，我们还阐述了该信号通路的特点，这些特点使其成为潜在的MS生物标志物和治疗靶点。
