Jöhl Alexander, Lang Stephanie, Ehrbar Stefanie, Guckenberger Matthias, Klöck Stephan, Meboldt Mirko, Schmid Daners Marianne
Biomed Tech (Berl). 2016 Oct 1;61(5):557-566. doi: 10.1515/bmt-2015-0187.
Tumor motion during radiation therapy increases the irradiation of healthy tissue. However, this problem may be mitigated by moving the patient via the treatment couch such that the tumor motion relative to the beam is minimized. The treatment couch poses limitations to the potential mitigation, thus the performance of the Protura (CIVCO) treatment couch was characterized and numerically modeled. The unknown parameters were identified using chirp signals and verified with one-dimensional tumor tracking. The Protura tracked chirp signals well up to 0.2 Hz in both longitudinal and vertical directions. If only the vertical or only the longitudinal direction was tracked, the Protura tracked well up to 0.3 Hz. However, there was unintentional yet substantial lateral motion in the former case. And during vertical motion, the extension caused rotation of the Protura around the lateral axis. The numerical model matched the Protura up to 0.3 Hz. Even though the Protura was designed for static positioning, it was able to reduce the tumor motion by 69% (median). The correlation coefficient between the tumor motion reductions of the Protura and the model was 0.99. Therefore, the model allows tumor-tracking results of the Protura to be predicted.
放射治疗期间肿瘤的运动增加了健康组织的受照剂量。然而,通过治疗床移动患者,使肿瘤相对于射束的运动最小化,这一问题可能会得到缓解。治疗床对这种潜在的缓解作用存在限制,因此对Protura(CIVCO)治疗床的性能进行了表征并建立了数值模型。使用啁啾信号识别未知参数,并通过一维肿瘤跟踪进行验证。Protura在纵向和垂直方向上都能很好地跟踪高达0.2 Hz的啁啾信号。如果仅跟踪垂直方向或仅跟踪纵向方向,Protura能很好地跟踪高达0.3 Hz的信号。然而,在前一种情况下存在无意但明显的横向运动。并且在垂直运动期间,伸展导致Protura绕横轴旋转。数值模型与Protura在高达0.3 Hz时匹配。尽管Protura是为静态定位设计的,但它能够将肿瘤运动减少69%(中位数)。Protura和模型的肿瘤运动减少之间的相关系数为0.99。因此,该模型可以预测Protura的肿瘤跟踪结果。