Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930-0194, Japan.
Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930-0194, Japan.
Psychiatry Res Neuroimaging. 2019 Jan 30;283:92-95. doi: 10.1016/j.pscychresns.2018.12.002. Epub 2018 Dec 5.
This MRI study examined the surface morphology of the orbitofrontal cortex (OFC) and its relation to social and cognitive functions in 38 individuals with at-risk mental state (ARMS) and 63 schizophrenia patients in comparison with 61 healthy controls. The ARMS and schizophrenia groups had increased right OFC Type III expression and fewer orbital sulci, which were partly associated with social and cognitive impairments. OFC underdevelopment may underlie vulnerability to psychosis, as well as the core clinical features of the illness.
这项 MRI 研究检查了 38 名有风险精神状态（ARMS）个体和 63 名精神分裂症患者的眶额皮层（OFC）表面形态及其与社会和认知功能的关系，并与 61 名健康对照进行了比较。ARMS 组和精神分裂症组的右侧 OFC III 型表达增加，眶沟减少，这与社会和认知障碍部分相关。OFC 发育不良可能是精神分裂症易感性的基础，也是该疾病的核心临床特征。
