外泌体在胰腺导管腺癌发病机制中的作用。

The role of exosomes in the pathogenesis of pancreatic ductal adenocarcinoma.

作者信息

Robinson Stuart M, Fan Lavender, White Steven A, Charnley Richard M, Mann Jelena

机构信息

Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom; Department of HPB Surgery, Freeman Hospital, Freeman Road, High Heaton, Newcastle upon Tyne, NE7 7DN, United Kingdom.

Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom.

出版信息

Int J Biochem Cell Biol. 2016 Jun;75:131-9. doi: 10.1016/j.biocel.2016.03.009. Epub 2016 Mar 24.

DOI:10.1016/j.biocel.2016.03.009

PMID:27017975

Abstract

Exosomes are small membrane bound vesicles secreted by cancer cells that have a cytosol rich in proteins and nucleic acids which are capable of modulating the phenotype of neighbouring cells which take them up. In this review we explore the mechanisms through which exosomes are able to impact on the pathogenesis of pancreatic ductal cancer through the modulation of tumour formation and development and exploitation of the tumour microenvironment to modulate both the adaptive and innate immune response. In addition we highlight the potential utility of exosomes not only as biomarkers of disease but also as tools to be used in the therapeutic armamentarium against this disease.

摘要

外泌体是癌细胞分泌的小膜泡，其富含蛋白质和核酸的胞质溶胶能够调节摄取它们的邻近细胞的表型。在本综述中，我们探讨了外泌体通过调节肿瘤形成和发展以及利用肿瘤微环境来调节适应性和先天性免疫反应，从而影响胰腺导管癌发病机制的机制。此外，我们强调了外泌体不仅作为疾病生物标志物的潜在用途，而且作为用于对抗这种疾病的治疗手段的工具的潜在用途。