Wang Ching-Chiung, Chang Chun-Jen, Hsu Ming-I
a School of Pharmacy, College of Pharmacy, Taipei Medical University , Taipei , Taiwan.
b Department of Internal Medicine , Section of Endocrinology and Metabolism, Taipei Medical University, Wan Fang Hospital , Taipei , Taiwan.
Gynecol Endocrinol. 2016 Sep;32(9):767-771. doi: 10.3109/09513590.2016.1163671. Epub 2016 Mar 28.
The aim of this study was to investigate the biomarkers of insulin resistance in non-obese women.
This was a retrospective study.
A total 229 non-obese women (Body mass index: BMI < 25) were evaluated.
MAIN OUTCOME MEASURE(S): Serum levels of various androgens, cardiovascular risk and metabolic components.
There were no significant differences in the prevalence of polycystic ovary syndrome (PCOS), hyperprolactinemia, or premature ovarian failure (POF) between the non-obese women with and without insulin resistance. Non-obese women with insulin had significantly higher serum thyroid stimulation hormone (TSH) levels and resistin and lower serum adiponectin levels than non-obese women without insulin resistance; however, the inflammatory biomarkers and serum androgen levels did not differ between the two groups. Furthermore, using step-wise multivariate regression analysis applied by the risk factors listed above, TSH was the only predictive factor for insulin resistance in non-obese reproductive-aged women.
Thyroid function should play an important role in developing insulin resistance for non-obese women. Serum androgens and inflammation might not contribute to insulin resistance in these women.
本研究旨在调查非肥胖女性胰岛素抵抗的生物标志物。
这是一项回顾性研究。
共评估了229名非肥胖女性（体重指数：BMI＜25）。
各种雄激素的血清水平、心血管风险和代谢成分。
有胰岛素抵抗和无胰岛素抵抗的非肥胖女性在多囊卵巢综合征（PCOS）、高泌乳素血症或卵巢早衰（POF）的患病率上无显著差异。有胰岛素抵抗的非肥胖女性血清促甲状腺激素（TSH）水平和抵抗素水平显著高于无胰岛素抵抗的非肥胖女性，而血清脂联素水平则较低；然而，两组之间的炎症生物标志物和血清雄激素水平并无差异。此外，使用上述危险因素进行逐步多因素回归分析，TSH是非肥胖育龄女性胰岛素抵抗的唯一预测因素。
甲状腺功能在非肥胖女性胰岛素抵抗的发生中应起重要作用。血清雄激素和炎症可能与这些女性的胰岛素抵抗无关。
