Kurashima Kazuyoshi, Takaku Yotaro, Ohta Chie, Takayanagi Noboru, Yanagisawa Tsutomu, Sugita Yutaka
Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Kumagaya, Saitama, Japan.
Int J Chron Obstruct Pulmon Dis. 2016 Mar 4;11:479-87. doi: 10.2147/COPD.S97343. eCollection 2016.
The COPD assessment test (CAT) consists of eight nonspecific scores of quality of life. The aim of this study was to compare the health-related quality of life and severity of airflow limitation in patients with asthma, COPD, and asthma-COPD overlap syndrome (ACOS) using the CAT.
We examined CAT and lung functions in 138 patients with asthma, 99 patients with COPD, 51 patients with ACOS, and 44 patients with chronic cough as a control. The CAT score was recorded in all subjects, and the asthma control test was also administered to patients with asthma and ACOS. The CAT scores were compared, and the relationships between the scores and lung function parameters were analyzed.
The total CAT scores and scores for cough, phlegm, and dyspnea were higher in patients with ACOS than in patients with asthma and COPD. The total CAT scores were correlated with the percent predicted forced expiratory volume in 1 second only in patients with COPD. The total CAT scores and dyspnea scores adjusted by the percent predicted forced expiratory volume in 1 second were higher in patients with ACOS than in patients with COPD and asthma. The CAT scores and asthma control test scores were more closely correlated in patients with ACOS than in patients with asthma.
Patients with ACOS have higher disease impacts and dyspnea sensation unproportional to the severity of airflow limitation.
慢性阻塞性肺疾病评估测试（CAT）由八个非特异性生活质量评分组成。本研究的目的是使用CAT比较哮喘、慢性阻塞性肺疾病（COPD）和哮喘-慢性阻塞性肺疾病重叠综合征（ACOS）患者的健康相关生活质量和气流受限严重程度。
我们检查了138例哮喘患者、99例COPD患者、51例ACOS患者和44例慢性咳嗽患者的CAT及肺功能，以慢性咳嗽患者作为对照。记录所有受试者的CAT评分，同时也对哮喘和ACOS患者进行哮喘控制测试。比较CAT评分，并分析评分与肺功能参数之间的关系。
ACOS患者的CAT总分以及咳嗽、咳痰和呼吸困难评分高于哮喘和COPD患者。仅在COPD患者中，CAT总分与1秒用力呼气容积预测值百分比相关。经1秒用力呼气容积预测值百分比校正后的CAT总分和呼吸困难评分，ACOS患者高于COPD和哮喘患者。与哮喘患者相比，ACOS患者的CAT评分与哮喘控制测试评分的相关性更强。
ACOS患者的疾病影响更大，且呼吸困难感与气流受限严重程度不成比例。
