Miyoshi I, Uchida H, Tsubota T, Kubonish I, Hiraki S, Kitajima K
Scand J Haematol. 1977 Oct;19(4):321-6. doi: 10.1111/j.1600-0609.1977.tb01481.x.
Peripheral leucocytes from 10 patients with chronic myelogenous leukaemia (CML) were cultured in liquid medium and observed morphologically for 6 to 10 weeks. All cultures showed in increased proportion of mature basophilis at about 3 weeks and most cultures consisted predominantly of mature basophilis at about 5 weeks. The results indicate preferential basophilic differentiation of CML leucocytes in vitro and are consistent with basophilia frequently observed in CML patients.
对10例慢性粒细胞白血病（CML）患者的外周血白细胞进行液体培养基培养，并进行6至10周的形态学观察。所有培养物在约3周时显示成熟嗜碱性粒细胞比例增加，大多数培养物在约5周时主要由成熟嗜碱性粒细胞组成。结果表明CML白细胞在体外优先向嗜碱性粒细胞分化，这与CML患者中经常观察到的嗜碱性粒细胞增多一致。
