Ogborn M R, Crocker J F, Grimm P C
Department of Paediatrics, Dalhousie University, Halifax, Nova Scotia, Canada.
Pediatr Nephrol. 1989 Jul;3(3):314-6. doi: 10.1007/BF00858540.
We report two paediatric renal transplant patients in whom interaction with the calcium channel blocking agent verapamil resulted in reduced cyclosporin A (CyA) elimination. Prior therapy with another calcium channel blocking agent, nifedipine, did not affect CyA pharmacokinetics. We speculate that verapamil reduced CyA elimination in children via an effect upon the microsomal oxidase system that is independent of calcium channel activity.
我们报告了两名小儿肾移植患者，他们与钙通道阻滞剂维拉帕米相互作用后，环孢素A（CyA）的消除减少。先前使用另一种钙通道阻滞剂硝苯地平治疗时，并未影响CyA的药代动力学。我们推测，维拉帕米通过对微粒体氧化酶系统产生作用，从而减少儿童体内CyA的消除，这种作用独立于钙通道活性。
