Agatstein E H, Farrer J H, Kaplan L M, Randazzo R F, Glassock R J, Kaufman J J
Transplantation. 1987 Sep;44(3):355-7. doi: 10.1097/00007890-198709000-00006.
Calcium channel blockade has been shown to prevent warm renal ischemic damage. The ability of verapamil to decrease the severity of acute tubular necrosis (ATN) after 24-hr cold storage and autotransplantation was studied in a randomized paired study of 12 dogs. Experimental animals pretreated with intraarterial verapamil and flushing of the harvested kidney with cold intracellular solution containing verapamil demonstrated significantly (P less than .05) greater renal function preservation over their matched controls. A subsequent nonpaired study of 6 dogs treated only with flushing of the harvested kidney with perfusate containing verapamil demonstrated no significant preservation advantage over controls. We conclude that verapamil, administered prior to the ischemic event, can enhance the protective effect of hypothermia and decrease the severity of ATN in ischemically injured kidneys.
钙通道阻滞已被证明可预防温暖性肾缺血损伤。在一项对12只狗进行的随机配对研究中，研究了维拉帕米在24小时冷藏和自体移植后降低急性肾小管坏死（ATN）严重程度的能力。用动脉内维拉帕米预处理并使用含维拉帕米的冷细胞内溶液冲洗收获的肾脏的实验动物，与匹配的对照组相比，肾功能保留明显更好（P小于0.05）。随后对6只仅用含维拉帕米的灌注液冲洗收获肾脏的狗进行的非配对研究表明，与对照组相比，没有显著的保留优势。我们得出结论，在缺血事件发生前给予维拉帕米，可以增强低温的保护作用，并降低缺血性损伤肾脏中ATN的严重程度。
