Department of Community Health Sciences, Cumming School of Medicine, Health Sciences Centre, University of Calgary, HBA 2935D, 3300 Hospital Dr NW, Calgary, AB, T2N 4N1, Canada.
Calgary Stroke Program, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Curr Neurol Neurosci Rep. 2016 May;16(5):42. doi: 10.1007/s11910-016-0646-5.
More than 800,000 people in North America suffer a stroke each year, with ischemic stroke making up the majority of these cases. The outcomes of ischemic stroke range from complete functional and cognitive recovery to severe disability and death; outcome is strongly associated with timely reperfusion treatment. Historically, ischemic stroke has been treated with intravenous thrombolytic agents with moderate success. However, five recently published positive trials have established the efficacy of endovascular treatment in acute ischemic stroke. In this review, we will discuss the history of stroke treatments moving from various intravenous thrombolytic drugs to intra-arterial thrombolysis, early mechanical thrombectomy devices, and finally modern endovascular devices. Early endovascular therapy failures, recent successes, and implications for current ischemic stroke management and future research directions are discussed.
每年有超过 80 万人在北美遭受中风，其中大多数是缺血性中风。缺血性中风的结果从完全的功能和认知恢复到严重残疾和死亡不等；结果与及时的再灌注治疗密切相关。历史上，缺血性中风曾用静脉溶栓药物治疗，但效果中等。然而，最近发表的五项积极试验已经证实了血管内治疗在急性缺血性中风中的疗效。在这篇综述中，我们将讨论从各种静脉溶栓药物到动脉内溶栓、早期机械血栓切除术装置，最后是现代血管内装置的中风治疗历史。讨论了早期血管内治疗失败、最近的成功以及对当前缺血性中风管理和未来研究方向的影响。
