Lloyd-Evans Emyr
School of Biosciences, Cardiff University, Cardiff CF10 3AX, Wales, UK
J Cell Biol. 2016 Mar 28;212(7):755-7. doi: 10.1083/jcb.201603037.
Acidic Ca(2+)stores are important sources of Ca(2+)during cell signaling but little is known about how Ca(2+)enters these stores. In this issue, Melchionda et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201510019) identify a Ca(2+)/H(+)exchanger (CAX) that is required for Ca(2+)uptake and cell migration in vertebrates.
酸性钙离子储存库是细胞信号传导过程中钙离子的重要来源,但关于钙离子如何进入这些储存库却知之甚少。在本期杂志中,梅尔基昂达等人(2016年。《细胞生物学杂志》。http://dx.doi.org/10.1083/jcb.201510019)鉴定出一种钙离子/氢离子交换器(CAX),它是脊椎动物中钙离子摄取和细胞迁移所必需的。