地中海贫血中肠道钙转运及其调节：钙与铁代谢之间的相互作用
Intestinal calcium transport and its regulation in thalassemia: interaction between calcium and iron metabolism.
作者信息
Lertsuwan Kornkamon, Wongdee Kannikar, Teerapornpuntakit Jarinthorn, Charoenphandhu Narattaphol
机构信息
Department of Biochemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok, 10400, Thailand.
Center of Calcium and Bone Research (COCAB), Faculty of Science, Mahidol University, Rama VI Road, Bangkok, 10400, Thailand.
出版信息
J Physiol Sci. 2018 May;68(3):221-232. doi: 10.1007/s12576-018-0600-1. Epub 2018 Feb 26.
Abstract
Osteoporosis and derangement of calcium homeostasis are common complications of thalassemia. Despite being an important process for bone and calcium metabolism, little is known about intestinal calcium transport in thalassemia. Recent reports of decreases in both intestinal calcium transport and bone mineral density in thalassemic patients and animal models suggested that defective calcium absorption might be a cause of thalassemic bone disorder. Herein, the possible mechanisms associated with intestinal calcium malabsorption in thalassemia are discussed. This includes alterations in the calcium transporters and hormonal controls of the transcellular and paracellular intestinal transport systems in thalassemia. In addition, the effects of iron overload on intestinal calcium absorption, and the reciprocal interaction between iron and calcium transport in thalassemia are elaborated. Understanding the mechanisms underlining calcium malabsorption in thalassemia would lead to development of therapeutic agents and mineral supplements that restore calcium absorption as well as prevent osteoporosis in thalassemic patients.
摘要
骨质疏松症和钙稳态紊乱是地中海贫血的常见并发症。尽管肠道钙转运是骨和钙代谢的重要过程，但人们对地中海贫血患者的肠道钙转运知之甚少。最近关于地中海贫血患者和动物模型中肠道钙转运和骨矿物质密度均下降的报道表明，钙吸收缺陷可能是地中海贫血性骨病的一个原因。本文讨论了与地中海贫血患者肠道钙吸收不良相关的可能机制。这包括地中海贫血患者中钙转运体的改变以及跨细胞和细胞旁肠道转运系统的激素调控。此外，还阐述了铁过载对肠道钙吸收的影响，以及地中海贫血中铁与钙转运之间的相互作用。了解地中海贫血患者钙吸收不良的潜在机制将有助于开发恢复钙吸收以及预防地中海贫血患者骨质疏松症的治疗药物和矿物质补充剂。
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