Sekita Yasuko, Murakami Keiji, Yumoto Hiromichi, Mizuguchi Hiroyuki, Amoh Takashi, Ogino Satoshi, Matsuo Takashi, Miyake Yoichiro, Fukui Hiroyuki, Kashiwada Yoshiki
a Department of Pharmacognosy , Institute of Biomedical Sciences, Tokushima University Graduate School , Tokushima , Japan.
b Department of Oral Microbiology, Institute of Biomedical Sciences , Tokushima University Graduate School , Tokushima , Japan.
Biosci Biotechnol Biochem. 2016 Jun;80(6):1205-13. doi: 10.1080/09168451.2016.1151339. Epub 2016 Mar 29.
Houttuynia cordata (HC) has been commonly used as many traditional remedies in local areas of Japan. Although many pharmacological activities of HC have been reported, the mechanism underlying the effect of HC remains unknown. We conducted the interview survey in Japan to verify how HC was actually used. The interview survey revealed that HC poultice (HCP) prepared from smothering fresh leaves of HC was most frequently used for the treatment of purulent skin diseases including furuncle and carbuncle with high effectiveness. Ethanol extract of HCP (eHCP) showed anti-bacterial effects against methicillin-resistant Staphylococcus aureus (MRSA), and showed an anti-biofilm activity against MRSA. eHCP showed dose-dependent inhibition of S. aureus lipoteichoic acid (LTA)-induced interleukin-8 and CCL20 production in human keratinocyte without any cytotoxicity. These results suggest that HCP is effective for skin abscess and its underlying mechanism might be the complicated multiple activities for both bacteria and host cells.
鱼腥草在日本当地一直被用作多种传统药物。尽管已报道了鱼腥草的许多药理活性，但其作用机制仍不清楚。我们在日本进行了访谈调查，以核实鱼腥草的实际使用方式。访谈调查显示，用新鲜鱼腥草叶闷制而成的鱼腥草敷剂（HCP）最常用于治疗包括疖和痈在内的化脓性皮肤病，且疗效显著。HCP的乙醇提取物（eHCP）对耐甲氧西林金黄色葡萄球菌（MRSA）具有抗菌作用，并对MRSA表现出抗生物膜活性。eHCP对人角质形成细胞中金黄色葡萄球菌脂磷壁酸（LTA）诱导的白细胞介素-8和CCL20的产生具有剂量依赖性抑制作用，且无任何细胞毒性。这些结果表明，HCP对皮肤脓肿有效，其潜在机制可能是对细菌和宿主细胞的复杂多种活性。
