Teichmann J V, Sieber G, Ludwig W D, Ruehl H
Department of Hematology and Oncology, Free University of Berlin, FRG.
Cancer. 1989 May 15;63(10):1990-3. doi: 10.1002/1097-0142(19890515)63:10<1990::aid-cncr2820631020>3.0.co;2-e.
Interferons (IFN) are known to modulate immune responses in an either stimulatory or inhibitory manner. Most of the knowledge about immunomodulatory activities of IFN comes from investigations of IFN effects on cells in vitro. This study examines the influence which long-term treatment with recombinant interferon-alpha 2 exerts on immune functions in cancer patients. Serial in vitro immune function studies of peripheral blood mononuclear cells were done to determine parameters of B-cell and T-cell functions as well as natural killer (NK)-cell activity. The authors detected profound suppression of in vitro immunoglobulin synthesis and lymphocyte proliferation as well as depression of NK-cell activity during IFN treatment. All suppressed immune functions normalized on discontinuation of IFN therapy. The authors conclude from these observations that, apart from their beneficial effects, IFN produce substantial immunosuppression.
已知干扰素（IFN）以刺激或抑制的方式调节免疫反应。关于IFN免疫调节活性的大部分知识来自于对IFN体外作用于细胞的研究。本研究探讨了重组干扰素α2长期治疗对癌症患者免疫功能的影响。对外周血单核细胞进行了系列体外免疫功能研究，以确定B细胞和T细胞功能参数以及自然杀伤（NK）细胞活性。作者发现，在IFN治疗期间，体外免疫球蛋白合成和淋巴细胞增殖受到显著抑制，NK细胞活性降低。在停止IFN治疗后，所有受抑制的免疫功能均恢复正常。作者从这些观察结果得出结论，IFN除了具有有益作用外，还会产生显著的免疫抑制作用。
