Crome P, Baksi A, Edwards J, Marley J
Orpington Hospital, Orpington, England.
Curr Med Res Opin. 1989;11(5):279-82. doi: 10.1185/03007998909115210.
An acute and chronic dosing pharmacokinetic study of the calcium antagonist nitrendipine was carried out in 8 normotensive volunteers (mean age 80.1 +/- 3.4 years) to investigate if drug accumulation occurred in the elderly. Subjects received 10 mg nitrendipine once daily by mouth for 8 days. Plasma nitrendipine concentrations before administration and at 0.5, 1, 2, 4, 6 and 8 hours after dosing were measured after the first and last dose. Comparison of the pharmacokinetic data from Days 1 and 8 failed to show any evidence of nitrendipine accumulation in these elderly subjects.
对8名血压正常的志愿者（平均年龄80.1±3.4岁）进行了钙拮抗剂尼群地平的急性和慢性给药药代动力学研究，以调查老年人是否会出现药物蓄积。受试者每天口服10毫克尼群地平，共8天。在首次给药和末次给药后，测量给药前以及给药后0.5、1、2、4、6和8小时的血浆尼群地平浓度。比较第1天和第8天的药代动力学数据，未发现这些老年受试者有尼群地平蓄积的任何证据。
