Pettit S H, Shaffer J L, Johns C W, Bennett R J, Irving M H
Department of Surgery, Hope Hospital, University of Manchester School of Medicine, Salford, United Kingdom.
Dig Dis Sci. 1989 Apr;34(4):559-66. doi: 10.1007/BF01536333.
Total body pool and intestinal absorption of ascorbic acid were studied in 12 patients undergoing operation for Crohn's disease (six with fistulae and six without) and in six control patients undergoing operation for reasons other than Crohn's disease. L-[carboxyl-14C]Ascorbic acid, 0.19-0.40 megabecquerels (MBq), was given orally. After a period of equilibration, the labeled ascorbic acid was flushed out of the patient's body tissues using large doses of unlabeled ascorbic acid. Intestinal absorption of ascorbic acid, assessed from the total cumulative urinary 14C recovery, was found to be similar in patients with fistulizing Crohn's disease (73.9 +/- 8.45%), those without fistulas (72.8 +/- 11.53%), and in controls (80.3 +/- 8.11%). Total body pools of ascorbic acid, calculated using the plasma 14C decay curves, were similar in patients with Crohn's disease with fistulas (17.1 +/- 5.91 mg/kg), patients without fistulas (9.6 +/- 3.58 mg/kg), and in controls (13.3 +/- 4.28 mg/kg). The results indicate that ascorbic acid absorption is normal in patients with both fistulizing and nonfistulizing Crohn's disease. The results suggest that routine supplements of vitamin C are not necessary unless oral ascorbic acid intake is low.
对12例接受克罗恩病手术的患者（6例有瘘管，6例无瘘管）以及6例因非克罗恩病原因接受手术的对照患者进行了抗坏血酸的全身储备和肠道吸收研究。口服给予0.19 - 0.40兆贝可勒尔（MBq）的L-[羧基-¹⁴C]抗坏血酸。经过一段时间的平衡后，使用大剂量未标记的抗坏血酸将标记的抗坏血酸从患者的身体组织中冲洗出来。从尿中¹⁴C的总累积回收率评估抗坏血酸的肠道吸收，发现有瘘管的克罗恩病患者（73.9 ± 8.45%）、无瘘管的患者（72.8 ± 11.53%）和对照患者（80.3 ± 8.11%）相似。使用血浆¹⁴C衰变曲线计算的抗坏血酸全身储备，有瘘管的克罗恩病患者（17.1 ± 5.91 mg/kg）、无瘘管的患者（9.6 ± 3.58 mg/kg）和对照患者（13.3 ± 4.28 mg/kg）相似。结果表明，有瘘管和无瘘管的克罗恩病患者的抗坏血酸吸收均正常。结果提示，除非口服抗坏血酸摄入量低，否则常规补充维生素C没有必要。
