Pettit S H, Irving M H
Dis Colon Rectum. 1987 Jul;30(7):552-7. doi: 10.1007/BF02554789.
Samples of maximally diseased and adjacent macroscopically normal intestine from 52 patients undergoing surgery for Crohn's disease were analyzed for ascorbate content; 26 of the patients had intestinal fistulas and 26 did not. Ascorbate analyses were also performed on samples of normal intestine from ten control patients. Diseased intestine from both groups of patients with Crohn's disease contained significantly more ascorbate than the adjacent macroscopically normal intestine. Their diseased intestine also contained significantly more ascorbate than normal intestine from controls. Whereas diseased intestine from patients without fistulas contained 47 percent more ascorbate than their normal intestine (P less than .001), the diseased intestine from patients with fistulas contained only 23 percent more ascorbate than their normal intestine (P less than .02). Patients with fistulas appear unable to concentrate as much ascorbate in their diseased intestine as patients without fistulas. This difference may be a factor in the pathogenesis of fistula formation in Crohn's disease because of the importance of ascorbate in collagen production.
对52例接受克罗恩病手术的患者，采集病变最严重处及相邻肉眼可见正常肠段的样本，分析其中抗坏血酸含量；26例患者有肠瘘，26例没有。对10例对照患者的正常肠段样本也进行了抗坏血酸分析。两组克罗恩病患者的病变肠段所含抗坏血酸均显著多于相邻肉眼可见正常肠段。他们的病变肠段所含抗坏血酸也显著多于对照患者的正常肠段。无肠瘘患者的病变肠段所含抗坏血酸比其正常肠段多47%（P小于0.001），有肠瘘患者的病变肠段所含抗坏血酸仅比其正常肠段多23%（P小于0.02）。有肠瘘的患者似乎无法像无肠瘘患者那样在病变肠段中浓缩那么多抗坏血酸。由于抗坏血酸在胶原蛋白生成中的重要性，这种差异可能是克罗恩病肠瘘形成发病机制中的一个因素。
