Borzenkov Mykola, Määttänen Anni, Ihalainen Petri, Collini Maddalena, Cabrini Elisa, Dacarro Giacomo, Pallavicini Piersandro, Chirico Giuseppe
Department of Physics "G. Occhialini", Nanomedicine Center, University of Milano-Bicocca , piazza della Scienza 3, 20126 Milan, Italy.
Laboratory of Physical Chemistry, Center for Functional Materials, Åbo Akademi University , Porthaninkatu 3-5, 20500 Turku, Finland.
ACS Appl Mater Interfaces. 2016 Apr 20;8(15):9909-16. doi: 10.1021/acsami.6b02983. Epub 2016 Apr 6.
Inkjet printing technology has brought significant advances in patterning various functional materials that can meet important challenges in personalized medical treatments. Indeed, patterning of photothermal active anisotropic gold nanoparticles is particularly promising for the development of low-cost tools for localized photothermal therapy. In the present work, stable inks containing PEGylated gold nanostars (GNSs) were prepared and inkjet printed on a pigment-coated paper substrate. A significant photothermal effect (ΔT ≅ 20 °C) of the printed patterns was observed under near infrared (NIR) excitation of the localized surface plasmon resonance (LSPR) of the GNS with low laser intensity (I ≅ 0.2 W/cm(2)). Besides the pronounced photothermal effect, we also demonstrated, as an additional valuable effect, the release of a model fluorescent thiol-terminated Bodipy dye (BDP-SH) from the printed gold surface, both under bulk heating and NIR irradiation. These preliminary results suggest the way of the development of a new class of low-cost, disposable, and smart devices for localized thermal treatments combined with temperature-triggered drug release.
喷墨打印技术在各种功能材料的图案化方面取得了重大进展，这些功能材料能够应对个性化医疗中的重要挑战。事实上，光热活性各向异性金纳米颗粒的图案化对于开发用于局部光热疗法的低成本工具特别有前景。在本工作中，制备了含有聚乙二醇化金纳米星（GNSs）的稳定墨水，并将其喷墨打印在颜料涂层纸基材上。在低激光强度（I≅0.2W/cm²）下，在GNS的局部表面等离子体共振（LSPR）的近红外（NIR）激发下，观察到打印图案具有显著的光热效应（ΔT≅20°C）。除了明显的光热效应外，我们还证明了，作为另一个有价值的效应，在整体加热和近红外照射下，模型荧光硫醇封端的Bodipy染料（BDP-SH）从打印的金表面释放。这些初步结果为开发一类新型的低成本、一次性和智能设备指明了方向，这类设备可用于局部热处理并结合温度触发的药物释放。
