Dipartimento di Chimica, Università degli Studi di Pavia, v.le Taramelli 12, 27100 Pavia, Italy.
Dipartimento di Fisica G. Occhialini, Università degli Studi di Milano-Bicocca, Piazza della Scienza, 3, 20126 Milano, Italy.
J Colloid Interface Sci. 2017 Nov 1;505:1055-1064. doi: 10.1016/j.jcis.2017.06.102. Epub 2017 Jul 1.
The synthesis of large pentatwinned five-branched gold nanostars (GNS) has been modified so to obtain overall dimensions shrunk to 60% and a lower branches aspect ratio, leading to a dramatic blue shift of their two near-infrared (NIR) localized surface plasmon resonances (LSPR) absorptions but still maintaining one LSPR in the biotransparent NIR range. The interactions of polyethylene glycol (PEG) coated large and shrunk GNS with SH-SY5Y cells revealed that the large ones (DCI - diameter of the circumference in which GNS can be inscribed=76nm) are internalized more efficiently than the shrunk ones (DCI=46nm), correlating with a decreased cells surviving fraction.
大五重孪晶五角星形金纳米星（GNS）的合成得到了改进，使其整体尺寸缩小到 60%，分支比例降低，导致其两个近红外（NIR）局域表面等离子体共振（LSPR）吸收发生明显蓝移，但仍保持一个 LSPR 在生物透明的近红外范围内。聚乙二醇（PEG）包覆的大尺寸和缩小尺寸的 GNS 与 SH-SY5Y 细胞的相互作用表明，大尺寸的 GNS（周长直径 DCI=76nm）比缩小尺寸的 GNS（DCI=46nm）更有效地被内化，这与细胞存活分数的降低有关。
