Baker Joseph S, Miranpuri Sarnarendra
J Am Podiatr Med Assoc. 2016 Mar;106(2):138-40. doi: 10.7547/14-094.
Perniosis, or chilblain, is an uncommon condition of the acral skin. Presented herein is a case report of a 65-year-old otherwise healthy construction worker with perniosis. He had a 3-year history of lesions on the fingers and toes brought on by cold, damp weather. On initial presentation, a biopsy sample was taken of a hallux lesion, and the patient was given a trial course of nifedipine therapy. Follow-up at 3 weeks showed complete relief of symptoms with nifedipine use, and the biopsy results confirmed the diagnosis. The etiology and pathogenesis of perniosis are reviewed. Differential diagnoses and treatment options are reviewed and discussed. Nifedipine therapy has been shown to be effective and should be considered the standard of care in the treatment of perniosis along with avoidance of cold, damp environments, with protection using gloves and warm socks.
冻疮,又称手足冻疮,是一种累及手足皮肤的罕见病症。本文报告一例65岁身体健康的建筑工人患冻疮的病例。他有3年手指和脚趾因寒冷潮湿天气出现皮损的病史。初次就诊时,对其拇趾皮损进行了活检取样,并给予患者硝苯地平治疗的试验疗程。3周后的随访显示,使用硝苯地平后症状完全缓解,活检结果确诊。本文对冻疮的病因和发病机制进行了综述。对鉴别诊断和治疗方案进行了回顾和讨论。硝苯地平治疗已被证明有效,在冻疮治疗中应被视为标准治疗方法,同时应避免寒冷潮湿环境,使用手套和保暖袜子进行防护。