鼻咽癌放疗后唾液阴离子变化：一项为期1年的前瞻性研究。
Salivary Anionic Changes after Radiotherapy for Nasopharyngeal Carcinoma: A 1-Year Prospective Study.
作者信息
Pow Edmond H N, Chen Zhuofan, Kwong Dora L W, Lam Otto L T
机构信息
Oral Rehabilitation, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.
Department of Oral Implantology, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China.
出版信息
PLoS One. 2016 Mar 31;11(3):e0152817. doi: 10.1371/journal.pone.0152817. eCollection 2016.
OBJECTIVES
To investigate the salivary anionic changes of patients with nasopharyngeal carcinoma (NPC) treated by radiotherapy.
MATERIAL AND METHODS
Thirty-eight patients with T1-4, N0-2, M0 NPC received conventional radiotherapy. Stimulated whole saliva was collected at baseline and 2, 6 and 12 months after radiotherapy. Salivary anions levels were measured using ion chromatography.
RESULTS
A reduction in stimulated saliva flow and salivary pH was accompanied by sustained changes in anionic composition. At 2 months following radiotherapy, there was a significant increase in chloride, sulphate, lactate and formate levels while significant reductions in nitrate and thiocyanate levels were found. No further changes in these anion levels were observed at 6 and 12 months. No significant changes were found in phosphate, acetate, or propionate levels throughout the study period.
CONCLUSIONS
Conventional radiotherapy has a significant and prolonged impact on certain anionic species, likely contributing to increased cariogenic properties and reduced antimicrobial capacities of saliva in NPC patients post-radiotherapy.
目的
研究接受放射治疗的鼻咽癌（NPC）患者唾液阴离子的变化情况。
材料与方法
38例T1-4、N0-2、M0期鼻咽癌患者接受了常规放疗。在放疗前基线以及放疗后2个月、6个月和12个月收集刺激全唾液。使用离子色谱法测量唾液阴离子水平。
结果
刺激唾液流量和唾液pH值降低的同时，阴离子组成持续变化。放疗后2个月，氯化物、硫酸盐、乳酸盐和甲酸盐水平显著升高，而硝酸盐和硫氰酸盐水平显著降低。在6个月和12个月时，这些阴离子水平未观察到进一步变化。在整个研究期间，磷酸盐、乙酸盐或丙酸盐水平未发现显著变化。
结论
常规放疗对某些阴离子种类有显著且持久的影响，这可能导致放疗后鼻咽癌患者唾液的致龋性增加和抗菌能力降低。
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