Rowley J D
Science. 1982 May 14;216(4547):749-51. doi: 10.1126/science.7079737.
Specific consistent chromosome translocations are regularly observed in certain human leukemias and lymphomas. For the myeloid leukemias, the constant recombinants are: the long arm of 9 to chromosome 22 in chronic myeloid leukemia, the long arm of 21 to chromosome 8 in acute myeloblastic leukemia, and the long arm of 17 to chromosome 15 in acute promyelocytic leukemia. Three related translocations are seen in Burkitt lymphoma and B cell acute lymphocytic leukemia; in each one, chromosome 8 is involved with chromosome 2, 14, or 22. Analysis of a complex translocation affecting chromosomes 8 and 14 indicates that the translocation of chromosome 8 to chromosome 14 is the critical constant rearrangement. The analysis of the DNA at the translocation sites of these chromosomes, rather than the reciprocal of each translocation, appears to be the most productive focus for initial study. The various immunoglobulin loci are located in chromosomes 2, 14, and 22, the chromosomes regularly involved in translocations in Burkitt lymphoma and B cell acute lymphocytic leukemia.
在某些人类白血病和淋巴瘤中经常观察到特定一致的染色体易位。对于髓系白血病，常见的重组情况是：慢性髓系白血病中9号染色体长臂易位至22号染色体；急性髓细胞白血病中21号染色体长臂易位至8号染色体；急性早幼粒细胞白血病中17号染色体长臂易位至15号染色体。在伯基特淋巴瘤和B细胞急性淋巴细胞白血病中可见三种相关易位；在每种情况中，8号染色体都与2号、14号或22号染色体发生易位。对涉及8号和14号染色体的复杂易位分析表明，8号染色体易位至14号染色体是关键的常见重排。对这些染色体易位位点的DNA进行分析，而非每种易位的相互易位情况，似乎是初始研究最有成效的重点。各种免疫球蛋白基因座位于2号、14号和22号染色体上，这几条染色体在伯基特淋巴瘤和B细胞急性淋巴细胞白血病的易位中经常涉及。
