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Drug delivery: Nanoparticles improve profile of molecularly targeted cancer drug.

作者信息

Cully Megan

出版信息

Nat Rev Drug Discov. 2016 Apr;15(4):231. doi: 10.1038/nrd.2016.60.

DOI:10.1038/nrd.2016.60
PMID:27032829
Abstract
摘要

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Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo.极光激酶抑制剂纳米颗粒在体内以有利的治疗指数靶向肿瘤。
Sci Transl Med. 2016 Feb 10;8(325):325ra17. doi: 10.1126/scitranslmed.aad2355.
实验测定沉积、尺寸选择的金纳米团簇竞争异构体之间的能量差。
Nat Commun. 2018 Apr 3;9(1):1323. doi: 10.1038/s41467-018-03794-9.
4
Accumulation of In-Labelled EGF-Au-PEG Nanoparticles in EGFR-Positive Tumours is Enhanced by Coadministration of Targeting Ligand.通过共同给予靶向配体可增强In标记的EGF-Au-PEG纳米颗粒在EGFR阳性肿瘤中的积累。
Nanotheranostics. 2017 Jun 8;1(3):232-243. doi: 10.7150/ntno.19952. eCollection 2017.
5
Aptamer-siRNA Chimeras: Discovery, Progress, and Future Prospects.适体-小干扰RNA嵌合体：发现、进展与未来展望
Biomedicines. 2017 Aug 9;5(3):45. doi: 10.3390/biomedicines5030045.
6
Dual-Mode Mass Spectrometric Imaging for Determination of in Vivo Stability of Nanoparticle Monolayers.双模质谱成像技术用于测定纳米粒子单层的体内稳定性。
ACS Nano. 2017 Jul 25;11(7):7424-7430. doi: 10.1021/acsnano.7b03711. Epub 2017 Jul 13.
7
Stepwise pH-responsive nanoparticles for enhanced cellular uptake and on-demand intracellular release of doxorubicin.用于增强细胞摄取和阿霉素按需胞内释放的逐步pH响应性纳米颗粒。
Int J Nanomedicine. 2017 Jun 6;12:4241-4256. doi: 10.2147/IJN.S129748. eCollection 2017.