Laganà M M, Pelizzari L, Scaccianoce E, Dipasquale O, Ricci C, Baglio F, Cecconi P, Baselli G
IRCCS, Fondazione Don Carlo Gnocchi ONLUS, Via Capecelatro 66, 20148 Milan, Italy.
IRCCS, Fondazione Don Carlo Gnocchi ONLUS, Via Capecelatro 66, 20148 Milan, Italy; Department of Electronics, Information and Bioengineering, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy.
Behav Neurol. 2016;2016:9717210. doi: 10.1155/2016/9717210. Epub 2016 Feb 29.
Background and Objectives. The hypothesized link between extracranial venous abnormalities and some neurological disorders awoke interest in the investigation of the internal jugular veins (IJVs). However, different IJV cross-sectional area (CSA) values are currently reported in literature. In this study, we introduced a semiautomatic method to measure and normalize the CSA and the degree of circularity (Circ) of IJVs along their whole length. Methods. Thirty-six healthy subjects (31.22 ± 9.29 years) were recruited and the 2D time-of-flight magnetic resonance venography was acquired with a 1.5 T Siemens scanner. The IJV were segmented on an axial slice, the contours were propagated in 3D. Then, IJV CSA and Circ were computed between the first and the seventh cervical levels (C1-C7) and normalized among subjects. Inter- and intrarater repeatability were assessed. Results. IJV CSA and Circ were significantly different among cervical levels (p < 0.001). A trend for side difference was observed for CSA (larger right IJV, p = 0.06), but not for Circ (p = 0.5). Excellent inter- and intrarater repeatability was obtained for all the measures. Conclusion. This study proposed a reliable semiautomatic method able to measure the IJV area and shape along C1-C7, and suitable for defining the normality thresholds for future clinical studies.
背景与目的。颅外静脉异常与某些神经系统疾病之间的假设联系引发了对颈内静脉（IJVs）研究的兴趣。然而，目前文献中报道的颈内静脉横截面积（CSA）值各不相同。在本研究中，我们引入了一种半自动方法来测量和标准化颈内静脉全长的CSA及圆度（Circ）。方法。招募了36名健康受试者（年龄31.22±9.29岁），使用1.5 T西门子扫描仪进行二维时间飞跃磁共振静脉成像。在轴位切片上分割颈内静脉，将轮廓在三维空间中传播。然后，计算第一至第七颈椎水平（C1 - C7）之间的颈内静脉CSA和Circ，并在受试者之间进行标准化。评估了评分者间和评分者内的重复性。结果。颈内静脉CSA和Circ在颈椎水平之间存在显著差异（p < 0.001）。观察到CSA存在侧别差异趋势（右侧颈内静脉较大，p = 0.06），但Circ不存在（p = 0.5）。所有测量均获得了出色的评分者间和评分者内重复性。结论。本研究提出了一种可靠的半自动方法，能够测量C1 - C7水平的颈内静脉面积和形状，适用于为未来临床研究确定正常阈值。
