Zivadinov Robert, Bastianello Stefano, Dake Michael D, Ferral Hector, Haacke E Mark, Haskal Ziv J, Hubbard David, Liasis Nikolaos, Mandato Kenneth, Sclafani Salvatore, Siddiqui Adnan H, Simka Marian, Zamboni Paolo
Department of Neurology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo; Buffalo Neuroimaging Analysis Center, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo.
Department of Neuroradiology, C. Mondino National Neurological Institute, University of Pavia.
J Vasc Interv Radiol. 2014 Nov;25(11):1785-94.e17. doi: 10.1016/j.jvir.2014.07.024. Epub 2014 Sep 23.
Under the auspices of the International Society for Neurovascular Disease (ISNVD), four expert panel committees were created from the ISNVD membership between 2011 and 2012 to determine and standardize noninvasive and invasive imaging protocols for detection of extracranial venous abnormalities indicative of chronic cerebrospinal venous insufficiency (CCSVI). The committees created working groups on color Doppler ultrasound (US), magnetic resonance (MR) imaging, catheter venography (CV), and intravascular US. Each group organized a workshop focused on its assigned imaging modality. Non-ISNVD members from other societies were invited to contribute to the various workshops. More than 60 neurology, radiology, vascular surgery, and interventional radiology experts participated in these workshops and contributed to the development of standardized noninvasive and invasive imaging protocols for the detection of extracranial venous abnormalities indicative of CCSVI. This ISNVD position statement presents the MR imaging and intravascular US protocols for the first time and describes refined color Doppler US and CV protocols. It also emphasizes the need for the use of for noninvasive and invasive multimodal imaging to diagnose adequately and monitor extracranial venous abnormalities indicative of CCSVI for open-label or double-blinded, randomized, controlled studies.
在国际神经血管疾病协会（ISNVD）的支持下，2011年至2012年间从ISNVD成员中组建了四个专家小组委员会，以确定并规范用于检测提示慢性脑脊髓静脉功能不全（CCSVI）的颅外静脉异常的非侵入性和侵入性成像方案。这些委员会成立了关于彩色多普勒超声（US）、磁共振（MR）成像、导管静脉造影（CV）和血管内超声的工作组。每个小组都组织了一次专注于其指定成像方式的研讨会。来自其他协会的非ISNVD成员受邀参与各个研讨会。60多位神经学、放射学、血管外科和介入放射学专家参加了这些研讨会，并为制定用于检测提示CCSVI的颅外静脉异常的标准化非侵入性和侵入性成像方案做出了贡献。本ISNVD立场声明首次介绍了MR成像和血管内超声方案，并描述了完善后的彩色多普勒超声和CV方案。它还强调了在开放标签或双盲、随机、对照研究中使用非侵入性和侵入性多模态成像来充分诊断和监测提示CCSVI的颅外静脉异常的必要性。
