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Highlight report: Erroneous sample annotation in a high fraction of publicly available genome-wide expression datasets.重点报告:在很大一部分公开的全基因组表达数据集中存在样本注释错误。
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Transcriptome based differentiation of harmless, teratogenetic and cytotoxic concentration ranges of valproic acid.基于转录组的丙戊酸无害、致畸和细胞毒性浓度范围的区分
EXCLI J. 2014 Dec 11;13:1281-2. eCollection 2014.

本文引用的文献

1
Test systems of developmental toxicity: state-of-the art and future perspectives.发育毒性测试系统:现状与未来展望。
Arch Toxicol. 2013 Dec;87(12):2037-42. doi: 10.1007/s00204-013-1154-x.
2
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.近年来,利用原代肝细胞、替代的肝细胞来源和非实质细胞的 2D 和 3D 体外系统在研究肝毒性、细胞信号转导和 ADME 的机制方面取得了进展。
Arch Toxicol. 2013 Aug;87(8):1315-530. doi: 10.1007/s00204-013-1078-5. Epub 2013 Aug 23.
3
Combining in vitro embryotoxicity data with physiologically based kinetic (PBK) modelling to define in vivo dose-response curves for developmental toxicity of phenol in rat and human.将体外胚胎毒性数据与基于生理学的动力学 (PBK) 模型相结合,为苯酚在大鼠和人体中的发育毒性定义体内剂量-反应曲线。
Arch Toxicol. 2013 Sep;87(9):1709-23. doi: 10.1007/s00204-013-1107-4. Epub 2013 Aug 14.
4
Monocrotophos in Gandaman village: India school lunch deaths and need for improved toxicity testing.印度甘达曼村的久效磷:学校午餐导致的死亡事件以及改进毒性测试的必要性
Arch Toxicol. 2013 Oct;87(10):1877-81. doi: 10.1007/s00204-013-1113-6. Epub 2013 Aug 13.
5
Evaluation of a human neurite growth assay as specific screen for developmental neurotoxicants.评价人类神经突生长检测法作为发育神经毒物的特异性筛选方法。
Arch Toxicol. 2013 Dec;87(12):2215-31. doi: 10.1007/s00204-013-1072-y. Epub 2013 May 14.
6
Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes.药代动力学解释了致癌剂引起的大鼠肝脏和培养肝细胞基因表达改变的体内/体外差异。
Arch Toxicol. 2013 Feb;87(2):337-45. doi: 10.1007/s00204-012-0999-8. Epub 2012 Dec 29.
7
Developmental neurotoxicity testing with human embryonic stem cell-derived in vitro systems: the novel FP7 ESNATS tests are available.利用人胚胎干细胞来源的体外系统进行发育神经毒性测试:新型的FP7 ESNATS测试可用。
Arch Toxicol. 2013 Jan;87(1):5-6. doi: 10.1007/s00204-012-0982-4.
8
Biomarker discovery in non-small cell lung cancer: integrating gene expression profiling, meta-analysis, and tissue microarray validation.非小细胞肺癌的生物标志物发现:整合基因表达谱分析、荟萃分析和组织微阵列验证。
Clin Cancer Res. 2013 Jan 1;19(1):194-204. doi: 10.1158/1078-0432.CCR-12-1139. Epub 2012 Oct 2.
9
Developmental neurotoxicity: the case of perfluoroalkylated compounds.发育神经毒性:全氟烷基化合物的案例
Arch Toxicol. 2012 Sep;86(9):1333-4. doi: 10.1007/s00204-012-0923-2.
10
Optimal strategies for sequential validation of significant features from high-dimensional genomic data.从高维基因组数据中逐步验证显著特征的最优策略。
J Toxicol Environ Health A. 2012;75(8-10):447-60. doi: 10.1080/15287394.2012.674912.

Transcriptomics in developmental toxicity testing.

作者信息

Bolt H M

机构信息

Leibniz Institut für Arbeitsforschung an der TU Dortmund, Leibniz Research Centre for Working Environment and Human Factors (IfADo), Ardeystrasse 67, 44139 Dortmund, Germany.

出版信息

EXCLI J. 2013 Dec 12;12:1027-9. eCollection 2013.

PMID:27034643
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4803008/
Abstract
摘要