Kalmarzi Rasoul Nasiri, Ahmadiniaz Mobin, Ataee Pedram, Babaei Erfan, Khalafi Behzad, Kooti Wesam, Darehbagh Ramyar Rahimi
Lung Diseases and Allergy Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Cellular & Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Recent Adv Inflamm Allergy Drug Discov. 2022;16(1):44-49. doi: 10.2174/2772270816666220314154951.
Chronic Urticaria is an allergic disorder that affects about 0.5 to 5% of the population in different communities. The disease's chronic course and long-term onset impose high economic and psychological costs on communities, adversely affecting individual and social life. Platelets play a role in various pathophysiological processes, including inflammation and immunology. Growing evidence suggests that platelets are actively involved in the pathogenesis of various inflammatory disorders, including inflammatory skin diseases. This study investigated the relationship between platelet and immunoglobulin-E markers and chronic idiopathic urticaria.
In the present case-control study, for the study population, patients with chronic idiopathic urticaria were referred to the Asthma and Allergy Clinic, and their caregivers were selected as the case and control groups, respectively. In this study, the mean platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and Total IgE values were simultaneously measured in the case and control groups. After taking 5CCs of venous blood, a blood sample was sent to the laboratory for platelet and IgE marker measurements.
100 patients and 100 healthy persons were evaluated in this study. The mean age in the case group was 34.95, and in the control group was 35.78 years. The results showed that the mean values of PLT, MPV, PDW, and Total IgE in the case group were 12.86, 9.83, 252190, and 147.05, respectively. The mean values of PLT, MPV, PDW, and Total IgE in the control group were 16.93, 7.53, 231410, and 15.29, respectively, which was statistically significant (P = 0.001). Moreover, total IgE in the Autologous Serum Skin Test (ASST) positive group was higher than ASST negative group and was statistically significant (P = 0.001).
The study results indicate the possible role of platelets in urticaria and inflammation. MPV in patients with chronic urticaria was higher than in the control group. The present study showed no significant relationship between the severity of urticaria and platelet markers, but there was a significant relationship between the severity of urticaria and ASST. Moreover, the severity of urticaria was higher in the positive skin test group.
慢性荨麻疹是一种过敏性疾病，在不同人群中的发病率约为0.5%至5%。该疾病的慢性病程和长期发作给社会带来了高昂的经济和心理成本，对个人和社会生活产生了不利影响。血小板在包括炎症和免疫在内的各种病理生理过程中发挥作用。越来越多的证据表明，血小板积极参与包括炎症性皮肤病在内的各种炎症性疾病的发病机制。本研究调查了血小板与免疫球蛋白E标志物和慢性特发性荨麻疹之间的关系。
在本病例对照研究中，对于研究人群，慢性特发性荨麻疹患者被转诊至哮喘与过敏诊所，分别选取其照顾者作为病例组和对照组。在本研究中，同时测量病例组和对照组的平均血小板计数（PLT）、平均血小板体积（MPV）、血小板分布宽度（PDW）和总IgE值。采集5毫升静脉血后，将血样送至实验室进行血小板和IgE标志物测量。
本研究共评估了100例患者和100名健康人。病例组的平均年龄为34.95岁，对照组为35.78岁。结果显示，病例组的PLT、MPV、PDW和总IgE的平均值分别为12.86、9.83、252190和147.05。对照组的PLT、MPV、PDW和总IgE的平均值分别为16.93、7.53、231410和15.29，差异具有统计学意义（P = 0.001）。此外，自体血清皮肤试验（ASST）阳性组的总IgE高于ASST阴性组，差异具有统计学意义（P = 0.001）。
研究结果表明血小板在荨麻疹和炎症中可能发挥作用。慢性荨麻疹患者的MPV高于对照组。本研究表明荨麻疹的严重程度与血小板标志物之间无显著关系，但荨麻疹的严重程度与ASST之间存在显著关系。此外，皮肤试验阳性组的荨麻疹严重程度更高。
