寄生虫感染孕妇和儿童的血清微量营养素：抗寄生虫治疗期间差异化补充的建议。

Serum Micronutrients in Helminth-infected Pregnant Women and Children: Suggestions for Differential Supplementation During Anti-helminthic Treatment.

机构信息

Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Department of Zoology, University of Ibadan, Ibadan, Nigeria.

出版信息

Ann Glob Health. 2015 Sep-Oct;81(5):705-10. doi: 10.1016/j.aogh.2015.10.001.

DOI:10.1016/j.aogh.2015.10.001

PMID:27036729

Abstract

BACKGROUND

The prevalence of helminth infection, which is known to affect nutritional status of the host, varies with age. The complex interplay between ages, nutrient requirements, and infection necessitated the need to recommend micronutrient supplementation during helminth infection among different age groups.

OBJECTIVE

The aim of this study was to determine the pattern of alteration in selected micronutrients in pregnant women and preschool- and school-aged children with helminth infection.

METHODS

We screened 245 pregnant women and 349 children for helminth infection. Of these, 17 (6.9%) pregnant women and 102 (29.2%) children (42 preschool- and 60 school-aged) had helminth infection. Only Ascaris lumbricoides was found in pregnant women, whereas the children had A lumbricoides, hookworm, Fasciola hepatica, and Trichuris trichiura infections. The helminth-infected (HI) pregnant women, preschool-aged children, and school-aged children were matched with helminth-negative (HN) pregnant women (n = 21), preschool-aged children (n = 42), and school-aged children (n = 50) who served as controls. Venous blood samples were obtained and analyzed for iron (Fe), zinc (Zn), selenium (Se), and vitamins A and C. Statistical analysis was done using Student's t test, and P < 0.05 was considered statistically significant.

FINDINGS

Serum levels of Fe, Zn, and Se were significantly lower in HI pregnant women than HN pregnant women. In preschool-aged children, serum levels of Fe, Zn, and vitamin A were significantly lower in the HI than in the HN group. Similarly, serum levels of Zn and vitamin A were significantly lower in HI school-aged children than in the HN group. However, serum levels of Se were significantly higher in HI children (both age groups) than in the corresponding HN group.

CONCLUSION

Helminth infection alters different types of micronutrients in children and pregnant women. Results from the present study therefore suggest monitoring Fe, Zn, or vitamin A supplementation with an anti-helminthic regimen.

摘要

背景

寄生虫感染的流行率因宿主的营养状况而异，且其流行率随年龄而变化。年龄、营养需求和感染之间的复杂相互作用，使得有必要针对不同年龄组的寄生虫感染推荐使用微量营养素补充剂。

目的

本研究旨在确定寄生虫感染孕妇和学龄前及学龄儿童体内选定微量营养素变化的模式。

方法

我们对 245 名孕妇和 349 名儿童进行了寄生虫感染筛查。其中，17 名（6.9%）孕妇和 102 名（29.2%）儿童（42 名学龄前儿童和 60 名学龄儿童）感染了寄生虫。仅在孕妇中发现了蛔虫，而儿童则感染了蛔虫、钩虫、肝片吸虫和鞭虫。将感染寄生虫的孕妇（HI 组）、学龄前儿童和学龄儿童与未感染寄生虫的孕妇（HN 组）（n=21）、学龄前儿童（n=42）和学龄儿童（n=50）进行匹配作为对照。采集静脉血样并分析铁（Fe）、锌（Zn）、硒（Se）以及维生素 A 和 C 的水平。采用 Student's t 检验进行统计学分析，P<0.05 为统计学显著差异。