Chen Jia-Yan, Zhu Hong-Cheng, Guo Qing, Shu Zheng, Bao Xu-Hui, Sun Feng, Qin Qin, Yang Xi, Zhang Chi, Cheng Hong-Yan, Sun Xin-Chen
Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China E-mail :
Asian Pac J Cancer Prev. 2016;17(3):1221-33. doi: 10.7314/apjcp.2016.17.3.1221.
To investigate any potential association between wine and breast cancer risk.
We quantitatively assessed associations by conducting a meta-analysis based on evidence from observational studies. In May 2014, we performed electronic searches in PubMed, EmBase and the Cochrane Library to identify studies examining the effect of wine drinking on breast cancer incidence. The relative risk (RR) or odds ratio (OR) were used to measure any such association.
The analysis was further stratified by confounding factors that could influence the results. A total of twenty-six studies (eight case-control and eighteen cohort studies) involving 21,149 cases were included in our meta-analysis. Our study demonstrated that wine drinking was associated with breast cancer risk. A 36% increase in breast cancer risk was observed across overall studies based on the highest versus lowest model, with a combined RR of 1.0059 (95%CI 0.97-1.05) in dose-response analysis. However, 5 g/d ethanol from wine seemed to have protective value from our non-linear model.
Our findings indicate that wine drinking is associated with breast cancer risk in a dose-dependent manner. High consumption of wine contributes to breast cancer risk with protection exerted by low doses. Further investigations are needed for clarification.
研究葡萄酒与乳腺癌风险之间的潜在关联。
我们通过基于观察性研究证据进行荟萃分析，定量评估关联。2014年5月，我们在PubMed、EmBase和Cochrane图书馆进行电子检索，以确定研究饮酒对乳腺癌发病率影响的研究。相对风险（RR）或比值比（OR）用于衡量此类关联。
分析进一步按可能影响结果的混杂因素分层。我们的荟萃分析纳入了26项研究（8项病例对照研究和18项队列研究），涉及21149例病例。我们的研究表明，饮酒与乳腺癌风险相关。基于最高与最低模型，在所有研究中观察到乳腺癌风险增加36%，剂量反应分析中合并RR为1.0059（9 [5%CI 0.97 - 1.05]）。然而，根据我们的非线性模型，来自葡萄酒的5克/天乙醇似乎具有保护作用。
我们的研究结果表明，饮酒与乳腺癌风险呈剂量依赖性关联。大量饮用葡萄酒会增加乳腺癌风险，低剂量则有保护作用。需要进一步调查以澄清。
