Song Weiye, Di Weihua, Qin Weiping
State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, PR China.
Dalton Trans. 2016 Apr 25;45(17):7443-9. doi: 10.1039/c5dt04908c.
Mesoporous-silica-coated Gd2O3:Eu/silica nanoparticles were synthesized by a multistep chemical process and characterized by XRD, TEM and N2 adsorption/desorption isotherms in terms of size, morphology and porosity. The core Gd2O3:Eu obtained by this method was highly luminescent upon excitation, giving the function of cell imaging upon incubation with the human cervical carcinoma (HeLa) cells. The outer porous silica shell is able to load the anticancer drug with a relatively high loading efficiency and release the loaded drugs at a sustained rate. The HeLa cells can be killed effectively on incubation with the core-shell porous particles loaded with the anticancer drug DOX. Meanwhile, the accumulation of mesoporous nanoparticles loaded with drugs in the target location could be monitored via fluorescence imaging. Therefore, the core-shell hybrid nanoparticles presented in this work are potential multifunctional biomaterials for smart detection or diagnosis and therapy in future biomedical engineering.
介孔二氧化硅包覆的Gd2O3:Eu/二氧化硅纳米粒子通过多步化学过程合成，并通过XRD、TEM和N2吸附/解吸等温线对其尺寸、形态和孔隙率进行了表征。通过该方法获得的核心Gd2O3:Eu在激发时具有高发光性，在与人宫颈癌（HeLa）细胞孵育时具有细胞成像功能。外部多孔二氧化硅壳能够以相对较高的负载效率负载抗癌药物，并以持续速率释放负载的药物。与负载抗癌药物DOX的核壳多孔颗粒孵育时，HeLa细胞可被有效杀死。同时，可通过荧光成像监测负载药物的介孔纳米粒子在目标位置的积累。因此，本文中呈现的核壳杂化纳米粒子是未来生物医学工程中用于智能检测或诊断及治疗的潜在多功能生物材料。
