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纳米陶瓷荧光粉的混合分层异质结构作为多重成像剂和活癌细胞迁移的示踪剂。

Hybrid Hierarchical Heterostructures of Nanoceramic Phosphors as Imaging Agents for Multiplexing and Living Cancer Cells Translocation.

机构信息

Department of Electroceramics, Instituto de Ceramica y Vidrio-CSIC, Kelsen 5, Campus de Cantoblanco, Madrid 28049, Spain.

Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom.

出版信息

ACS Appl Bio Mater. 2021 May 17;4(5):4105-4118. doi: 10.1021/acsabm.0c01417. Epub 2021 Mar 10.

DOI:10.1021/acsabm.0c01417
PMID:34056563
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8155200/
Abstract

Existing fluorescent labels used in life sciences are based on organic compounds with limited lifetime or on quantum dots which are either expensive or toxic and have low kinetic stability in biological environments. To address these challenges, luminescent nanomaterials have been conceived as hierarchical, core-shell structures with spherical morphology and highly controlled dimensions. These tailor-made nanophosphors incorporate Ln:YVO nanoparticles (Ln = Eu(III) and Er(III)) as 50 nm cores and display intense and narrow emission maxima centered at ∼565 nm. These cores can be encapsulated in silica shells with highly controlled dimensions as well as functionalized with chitosan or PEG5000 to reduce nonspecific interactions with biomolecules in living cells. Confocal fluorescence microscopy in living prostate cancer cells confirmed the potential of these platforms to overcome the disadvantages of commercial fluorophores and their feasibility as labels for multiplexing, biosensing, and imaging in life science assays.

摘要

现有的生命科学用荧光标记物基于有机化合物，其寿命有限，或者基于量子点，量子点要么昂贵，要么有毒，在生物环境中的动力学稳定性低。为了解决这些挑战，人们设计了具有球形形态和高度可控尺寸的层状核壳结构的发光纳米材料。这些定制的纳米荧光粉将 Ln:YVO 纳米颗粒（Ln = Eu(III) 和 Er(III))作为 50nm 核，并显示出强烈而狭窄的发射峰，中心位于 ∼565nm。这些核可以被包裹在具有高度可控尺寸的二氧化硅壳中，并通过壳聚糖或 PEG5000 进行功能化，以减少与活细胞中生物分子的非特异性相互作用。在活前列腺癌细胞中的共聚焦荧光显微镜证实了这些平台克服商业荧光团缺点的潜力，以及它们作为用于多重分析、生物传感和成像的标记物的可行性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e43/8155200/1ab7d8580422/mt0c01417_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e43/8155200/1f96388b9a93/mt0c01417_0001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e43/8155200/48a27ca61948/mt0c01417_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e43/8155200/9bba42c3cf8b/mt0c01417_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e43/8155200/a7e3f36d49b0/mt0c01417_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e43/8155200/655b1aa91c44/mt0c01417_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e43/8155200/5712599781b5/mt0c01417_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e43/8155200/1ab7d8580422/mt0c01417_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e43/8155200/1f96388b9a93/mt0c01417_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e43/8155200/f98352f08d09/mt0c01417_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e43/8155200/48a27ca61948/mt0c01417_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e43/8155200/9bba42c3cf8b/mt0c01417_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e43/8155200/a7e3f36d49b0/mt0c01417_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e43/8155200/655b1aa91c44/mt0c01417_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e43/8155200/5712599781b5/mt0c01417_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e43/8155200/1ab7d8580422/mt0c01417_0007.jpg

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