He Mingjing, Zhou Zhuan, Shah Anil A, Hong Yang, Chen Qianming, Wan Yong
Department of Cell Biology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Hillman Cancer Center, 5117 Centre Avenue, HCC2.6c, Pittsburgh, PA 15213 USA ; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 Sichuan Peoples' Republic of China.
Department of Cell Biology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Hillman Cancer Center, 5117 Centre Avenue, HCC2.6c, Pittsburgh, PA 15213 USA.
Cell Div. 2016 Mar 31;11:4. doi: 10.1186/s13008-016-0013-6. eCollection 2016.
PTMs (posttranslational modifications) such as ubiquitylation, sumoylation, acetylation and protein methylation are pivotal modifiers that determine the activation, deactivation or subcellular localization of signaling proteins, facilitating the initiation, amplification and transduction of signaling. Accumulating evidence suggest that several key signaling molecules in Hippo signaling pathway are tightly regulated by various types of PTMs. Malfunction of these critical signaling modules such as YAP/TAZ, MAT1/2 and LATS1/2 due to deregulated PTMs has been linked to a variety of human diseases such as cancer. In this review article, we summarized the current understanding of the impact of PTMs in regulating Hippo signaling pathway and further discussed the potential therapeutic intervention from the view of PTMs and Hippo pathway.
泛素化、SUMO化、乙酰化和蛋白质甲基化等翻译后修饰（PTM）是关键的修饰因子，它们决定信号蛋白的激活、失活或亚细胞定位，促进信号的起始、放大和转导。越来越多的证据表明，Hippo信号通路中的几个关键信号分子受到各种类型PTM的严格调控。由于PTM失调导致的这些关键信号模块（如YAP/TAZ、MAT1/2和LATS1/2）功能异常与多种人类疾病（如癌症）有关。在这篇综述文章中，我们总结了目前对PTM在调节Hippo信号通路中的影响的理解，并从PTM和Hippo通路的角度进一步讨论了潜在的治疗干预措施。
