Department of MicrobiologyCarver College of MedicineUniversity of IowaIowa CityIA52242USA; Interdisciplinary Program in Molecular and Cellular BiologyUniversity of IowaIowa CityIA52242USA.
Immun Inflamm Dis. 2015 Dec 7;4(1):4-23. doi: 10.1002/iid3.92. eCollection 2016 Mar.
Host cells respond to viral infections by activating immune response genes that are not only involved in inflammation, but may also predispose cells to cancerous transformation. One such gene is BST-2, a type II transmembrane protein with a unique topology that endows it tethering and signaling potential. Through this ability to tether and signal, BST-2 regulates host response to viral infection either by inhibiting release of nascent viral particles or in some models inhibiting viral dissemination. However, despite its antiviral functions, BST-2 is involved in disease manifestation, a function linked to the ability of BST-2 to promote cell-to-cell interaction. Therefore, modulating BST-2 expression and/or activity has the potential to influence course of disease.
宿主细胞通过激活免疫反应基因来应对病毒感染，这些基因不仅参与炎症反应，还可能使细胞易于发生癌变。BST-2 就是这样一个基因，它是一种具有独特拓扑结构的 II 型跨膜蛋白，赋予其固定和信号转导的潜力。通过这种固定和信号转导的能力，BST-2 调节宿主对病毒感染的反应，要么抑制新形成的病毒颗粒的释放，要么在某些模型中抑制病毒的传播。然而，尽管 BST-2 具有抗病毒功能，但它也参与疾病的表现，这一功能与 BST-2 促进细胞间相互作用的能力有关。因此，调节 BST-2 的表达和/或活性有可能影响疾病的进程。
