Pescador R, Porta R, Conz A, Mantovani M, Prino G
Crinos Biological Research Laboratories, Villa Guardia Como, Italy.
Life Sci. 1989;44(12):789-97. doi: 10.1016/0024-3205(89)90376-7.
Defibrotide, (D) an antithrombotic agent, when administered i.v. to cholesterol-fed rabbits decreased cholesterol in the aorta without changing total plasma cholesterol, triglyceride or phospholipid, nor the cholesterol, triglyceride, phospholipid and protein of plasma lipoproteins. Platelet aggregation was decreased in rabbits treated with D. There were fewer vascular lesions in the hearts and kidneys of animals treated with D than in animals fed cholesterol and treated with placebo. These data suggest that the antithrombotic activity of D and its ability to reduce platelet sensitivity could help to reduce the amount of cholesterol in the cardiovascular system in atherosclerosis-prone situations.
去纤苷（D）是一种抗血栓形成剂，静脉注射给予用胆固醇喂养的兔子时，可降低主动脉中的胆固醇，而不改变血浆总胆固醇、甘油三酯或磷脂，也不改变血浆脂蛋白中的胆固醇、甘油三酯、磷脂和蛋白质。用D治疗的兔子血小板聚集减少。与喂食胆固醇并用安慰剂治疗的动物相比，用D治疗的动物心脏和肾脏中的血管病变更少。这些数据表明，D的抗血栓形成活性及其降低血小板敏感性的能力可能有助于在易患动脉粥样硬化的情况下减少心血管系统中的胆固醇含量。
