肝素与多肽杂化纳米粒子的共组装用于仿生递药和抗血栓治疗。
Co-Assembly of Heparin and Polypeptide Hybrid Nanoparticles for Biomimetic Delivery and Anti-Thrombus Therapy.
机构信息
National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China.
University of Chinese Academy of Sciences, Beijing, 100049, China.
出版信息
Small. 2016 Sep;12(34):4719-25. doi: 10.1002/smll.201600328. Epub 2016 Apr 4.
Biomimetic delivery carriers using polypeptide/heparin hybrid nanoparticles that are adsorbed onto red blood cells for extended blood circulation time have been developed. This might open up an avenue to promote the innovations and advances of biomimetic, stimuli-responsive drug delivery, especially for the site-specific treatment of intravascular diseases such as thrombosis.
采用多肽/肝素杂化纳米粒子作为仿生递药载体，通过吸附在红细胞表面延长血液循环时间的方法已经得到了发展。这可能为促进仿生、刺激响应型药物递药的创新和进步开辟了一条途径，特别是在血栓等血管内疾病的靶向治疗方面。
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