Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 27695, USA.
Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Adv Mater. 2016 Nov;28(43):9573-9580. doi: 10.1002/adma.201603463. Epub 2016 Sep 14.
A platelet-membrane-coated biomimetic nanocarrier, which can sequentially target the bone microenvironment and myeloma cells to enhance the drug availability at the myeloma site and decrease off-target effects, is developed for inhibiting multiple myeloma growth and simultaneously eradicating thrombus complication.
一种血小板膜包覆的仿生纳米载体，能够顺序靶向骨髓瘤细胞的骨微环境，增强骨髓瘤部位的药物可用性，减少脱靶效应，用于抑制多发性骨髓瘤的生长并同时消除血栓并发症。
