小GTP酶Rab13对癌细胞行为的调控
Regulation of Cancer Cell Behavior by the Small GTPase Rab13.
作者信息
Ioannou Maria S, McPherson Peter S
机构信息
From the Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
From the Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
出版信息
J Biol Chem. 2016 May 6;291(19):9929-37. doi: 10.1074/jbc.R116.715193. Epub 2016 Apr 4.
Abstract
The members of the Rab family of GTPases are master regulators of cellular membrane trafficking. With ∼70 members in humans, Rabs have been implicated in all steps of membrane trafficking ranging from vesicle formation and transport to vesicle docking/tethering and fusion. Vesicle trafficking controls the localization and levels of a myriad of proteins, thus regulating cellular functions including proliferation, metabolism, cell-cell adhesion, and cell migration. It is therefore not surprising that impairment of Rab pathways is associated with diseases including cancer. In this review, we highlight evidence supporting the role of Rab13 as a potent driver of cancer progression.
摘要
GTP 酶 Rab 家族成员是细胞膜运输的主要调节因子。人类 Rab 家族约有 70 个成员，参与了从囊泡形成、运输到囊泡对接/拴系及融合的细胞膜运输的各个步骤。囊泡运输控制着大量蛋白质的定位和水平，从而调节包括增殖、代谢、细胞间黏附及细胞迁移在内的细胞功能。因此，Rab 途径受损与包括癌症在内的疾病相关也就不足为奇了。在本综述中，我们重点介绍了支持 Rab13 作为癌症进展有力驱动因素作用的证据。
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