用于合成基于双功能化β(3)-肽的水凝胶的正交策略。
Orthogonal strategy for the synthesis of dual-functionalised β(3)-peptide based hydrogels.
作者信息
Kulkarni Ketav, Motamed Sepideh, Habila Nathan, Perlmutter Patrick, Forsythe John S, Aguilar Marie-Isabel, Del Borgo Mark P
机构信息
Monash Biomedicine Discovery Institute and Department of Biochemistry & Molecular Biology, Monash University, Clayton Vic, 3800, Australia.
出版信息
Chem Commun (Camb). 2016 Apr 30;52(34):5844-7. doi: 10.1039/c6cc00624h. Epub 2016 Apr 5.
We have described a new class of hydrogelator based on helical β(3)-peptides carrying a bioactive payload. The β(3)-peptides self-assemble in aqueous solution to form a nanofibrous mesh resulting in a stable hydrogel. The simple design provides the versatility for attaching different functional payloads to the β(3)-peptide scaffold to develop new materials.
我们描述了一种基于携带生物活性负载的螺旋β(3)-肽的新型水凝胶剂。β(3)-肽在水溶液中自组装形成纳米纤维网，从而形成稳定的水凝胶。这种简单的设计为将不同的功能性负载连接到β(3)-肽支架上以开发新材料提供了通用性。
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