Kulkarni Ketav, Habila Nathan, Del Borgo Mark P, Aguilar Marie-Isabel
Department of Biochemistry and Molecular Biology and Biomedicine Discovery Institute, Monash Univdersity, Melbourne, VIC, Australia.
Front Chem. 2019 Feb 15;7:70. doi: 10.3389/fchem.2019.00070. eCollection 2019.
Self-assembly is the spontaneous organization of small components into higher-order structures facilitated by the collective balance of non-covalent interactions. Peptide-based self-assembly systems exploit the ability of peptides to adopt distinct secondary structures and have been used to produce a range of well-defined nanostructures, such as nanotubes, nanofibres, nanoribbons, nanospheres, nanotapes, and nanorods. While most of these systems involve self-assembly of α-peptides, more recently β-peptides have also been reported to undergo supramolecular self-assembly, and have been used to produce materials-such as hydrogels-that are tailored for applications in tissue engineering, cell culture and drug delivery. This review provides an overview of self-assembled peptide nanostructures obtained via the supramolecular self-assembly of short β-peptide foldamers with a specific focus on N-acetyl-β-peptides and their applications as bio- and nanomaterials.
自组装是指小分子成分在非共价相互作用的集体平衡作用下自发组织形成高阶结构的过程。基于肽的自组装系统利用了肽形成独特二级结构的能力，并已用于制备一系列定义明确的纳米结构，如纳米管、纳米纤维、纳米带、纳米球、纳米带和纳米棒。虽然这些系统大多涉及α-肽的自组装，但最近也有报道称β-肽会发生超分子自组装，并已用于制备适用于组织工程、细胞培养和药物递送等应用的材料，如水凝胶。本文综述了通过短β-肽折叠体的超分子自组装获得的自组装肽纳米结构，特别关注N-乙酰-β-肽及其作为生物材料和纳米材料的应用。
