Panda Saurav, Sankari Malaiappan, Satpathy Anurag, Jayakumar Doraiswamy, Mozzati Marco, Mortellaro Carmen, Gallesio Giorgia, Taschieri Silvio, Del Fabbro Massimo
*Department of Periodontics and Oral Implantology, Institute of Dental Sciences, Siksha 'O' Anusandhan University, Bhubaneswar, Odisha†Department of Periodontia, Saveetha Dental College and Hospitals, Saveetha University, Chennai, Tamil Nadu, India‡SIOM Oral Surgery and Implantology Center, Turin§Department of Health Sciences "A. Avogadro," University of Eastern Piedmont, Novara||Department of Medicine, Surgery and Dentistry, Università degli Studi di Milano¶IRCCS Istituto Ortopedico Galeazzi, Milano, Italy.
J Craniofac Surg. 2016 May;27(3):691-6. doi: 10.1097/SCS.0000000000002524.
Autologous platelet-rich fibrin (PRF) and barrier membranes in the treatment of intrabony defects in chronic periodontitis patients have shown significant clinical benefits. This study evaluates the additive effect of autologous PRF in combination with a barrier membrane versus the use of barrier membrane alone for the treatment of intrabony defects in chronic periodontitis patients.
A randomized split-mouth design was used. Sixteen patients with 32 paired intrabony defects were included. In each patient 1 defect was treated using a resorbable collagen membrane along with PRF (test group) and the other defect by guided tissue regeneration alone (control group). The following clinical parameters were measured at baseline and after 9 months: plaque index, modified sulcus bleeding index, probing pocket depth, clinical attachment level, and gingival marginal level. The radiographic defect depth was also assessed at baseline and after 9 months.
Test group showed a statistically significant improvement for probing depth (P = 0.002), clinical attachment level (P = 0.001), and radiographic defect depth (P < 0.001) after 9 months as compared with the control sites. Radiographic defect depth reduction was 58.19 ± 13.24% in the test group as compared with 24.86 ± 9.94% reduction in the control group.
The adjunctive use of PRF in combination with barrier membrane is more effective in the treatment of intrabony defects in chronic periodontitis as compared with barrier membrane alone.
自体富血小板纤维蛋白（PRF）和屏障膜在慢性牙周炎患者骨内缺损的治疗中已显示出显著的临床益处。本研究评估自体PRF联合屏障膜与单独使用屏障膜治疗慢性牙周炎患者骨内缺损的附加效果。
采用随机分口设计。纳入16例患者，共32对骨内缺损。在每位患者中，1个缺损采用可吸收胶原膜联合PRF治疗（试验组），另1个缺损仅采用引导组织再生治疗（对照组）。在基线和9个月后测量以下临床参数：菌斑指数、改良龈沟出血指数、探诊袋深度、临床附着水平和牙龈边缘水平。在基线和9个月后还评估了影像学缺损深度。
与对照部位相比，试验组在9个月后探诊深度（P = 0.002）、临床附着水平（P = 0.001）和影像学缺损深度（P < 0.001）有统计学意义的改善。试验组影像学缺损深度减少58.19 ± 13.24%，而对照组减少24.86 ± 9.94%。
与单独使用屏障膜相比，PRF联合屏障膜辅助治疗慢性牙周炎骨内缺损更有效。
