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采用分牙嵴技术和富血小板纤维蛋白与纳米骨联合牙种植体与单纯富血小板纤维蛋白治疗萎缩上颌骨的骨变化的断层评估：随机对照试验。

Tomographic assessment of bone changes in atrophic maxilla treated by split-crest technique and dental implants with platelet-rich fibrin and NanoBone versus platelet-rich fibrin alone: Randomized controlled trial.

机构信息

Department of Periodontology, Faculty of Dentistry, Modern Sciences and Arts University, Giza, Egypt.

Department of Periodontology, Faculty of Dentistry, Cairo University, El-Manial, Cairo, 11553, Egypt.

出版信息

BMC Oral Health. 2024 Jun 14;24(1):691. doi: 10.1186/s12903-024-04420-5.

DOI:10.1186/s12903-024-04420-5
PMID:38877464
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11177399/
Abstract

BACKGROUND

This study evaluated the clinical benefits of adding NanoBone with split-crest technique and simultaneous implant placement covered with platelet-rich fibrin membrane in horizontally deficient maxillary ridges in terms of crestal and horizontal bone changes and patient morbidity.

METHODS

Forty patients indicated for maxillary ridge splitting and simultaneous implant placement were assigned randomly to the study groups: control group (Platelet Rich Fibrin membrane) and test group (Platelet Rich Fibrin membrane + Nanobone). The Cone Beam Computed Tomography Fusion technique was utilized to assess crestal and horizontal bone changes after five months of the surgical procedure. Patient morbidity was recorded for one week post-surgical.

RESULTS

Five months post-surgical, buccal crestal bone resorption was 1.26 ± 0.58 mm for the control group and 1.14 ± 0.63 mm for the test group. Lingual crestal bone resorption was 1.40 ± 0.66 mm for the control group and 1.47 ± 0.68 mm for the test group. Horizontal bone width gain was 1.46 ± 0.44 mm for the control group and 1.29 ± 0.73 mm for the test group. There was no significant statistical difference between study groups regarding crestal and horizontal bone changes and patient morbidity.

CONCLUSIONS

The tomographic assessment of NanoBone addition in this study resulted in no statistically significant difference between study groups regarding crestal and horizontal bone changes and patient morbidity. More randomized controlled clinical trials on gap fill comparing different bone grafting materials versus no grafting should be conducted.

GOV REGISTRATION NUMBER

NCT02836678, 13 January 2017.

摘要

背景

本研究评估了在水平骨量不足的上颌骨嵴中，使用 Split-crest 技术和富血小板纤维蛋白膜覆盖同时植入物的情况下，添加 NanoBone 的临床益处，包括在嵴顶和水平骨变化以及患者发病率方面。

方法

将 40 名需要上颌骨嵴分裂和同时植入物的患者随机分配到研究组：对照组（富血小板纤维蛋白膜）和实验组（富血小板纤维蛋白膜+NanoBone）。使用 Cone Beam Computed Tomography Fusion 技术评估手术后 5 个月的嵴顶和水平骨变化。记录手术后一周的患者发病率。

结果

手术后 5 个月，对照组颊侧嵴顶骨吸收为 1.26±0.58mm，实验组为 1.14±0.63mm。对照组舌侧嵴顶骨吸收为 1.40±0.66mm，实验组为 1.47±0.68mm。对照组水平骨宽度增加为 1.46±0.44mm，实验组为 1.29±0.73mm。两组在嵴顶和水平骨变化以及患者发病率方面均无统计学差异。

结论

在本研究中，对 NanoBone 加用的断层评估结果表明，两组在嵴顶和水平骨变化以及患者发病率方面均无统计学差异。应该进行更多的随机对照临床试验，比较不同骨移植材料与不移植的间隙填充效果。

注册号

NCT02836678，2017 年 1 月 13 日。

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