Pradeep A R, Shetty Sharath Kumara, Garg Garima, Pai Sujatha
Department of Periodontics, Government Dental College and Research Institute, Bangalore, Karnataka, India.
J Periodontol. 2009 Jan;80(1):62-71. doi: 10.1902/jop.2009.080214.
The goal of periodontal therapy has always been the regeneration of lost attachment apparatus. The use of platelet-rich plasma (PRP) plus anorganic bovine-derived matrix and peptide 15 (ABM/P-15) for periodontal regenerative therapy offers a potentially useful modality for treating periodontal osseous defects. However, it is unknown whether a combination of these materials enhances the outcome of periodontal regenerative therapy. Therefore, this study was carried out to compare the effectiveness of the two regenerative techniques (autologous PRP plus ABM/P-15 versus autologous PRP) in treating intrabony defects in humans by analyzing the clinical and radiologic parameters.
Using a split-mouth design, 28 intrabony defects were treated with autologous PRP (control) or a combination of autologous PRP and ABM/P-15 (test). Clinical parameters such as plaque index, sulcus bleeding index, probing depth, attachment level, and gingival marginal level were recorded at baseline and 9 months postoperatively. Hard tissue measurements such as defect fill, defect resolution, and change in alveolar crest height were also recorded using spiral computed tomography (CT).
A statistically significant difference was observed in all clinical parameters in the test group compared to the control group. Furthermore, spiral CT images revealed significantly greater bone fill in the test group.
A combination of PRP plus ABM/P-15 was more effective than PRP alone in the treatment of intrabony defects. Further studies using a larger sample size are necessary to confirm the results of the present study.
牙周治疗的目标一直是使丧失的附着装置再生。使用富含血小板血浆（PRP）加无机牛源基质和肽15（ABM/P-15）进行牙周再生治疗为治疗牙周骨缺损提供了一种潜在有用的方法。然而，这些材料的组合是否能提高牙周再生治疗的效果尚不清楚。因此，本研究通过分析临床和放射学参数，比较两种再生技术（自体PRP加ABM/P-15与自体PRP）治疗人类骨内缺损的有效性。
采用分口设计，28例骨内缺损分别用自体PRP（对照组）或自体PRP与ABM/P-15的组合（试验组）进行治疗。在基线和术后9个月记录临床参数，如菌斑指数、龈沟出血指数、探诊深度、附着水平和牙龈边缘水平。还使用螺旋计算机断层扫描（CT）记录硬组织测量结果，如缺损填充、缺损分辨率和牙槽嵴高度变化。
与对照组相比，试验组所有临床参数均有统计学意义上的显著差异。此外，螺旋CT图像显示试验组的骨填充明显更多。
PRP加ABM/P-15的组合在治疗骨内缺损方面比单独使用PRP更有效。需要进一步进行更大样本量的研究来证实本研究的结果。
