诱导细菌对宿主抗菌肽产生交叉耐药性：一种令人担忧的现象。
Induced Bacterial Cross-Resistance toward Host Antimicrobial Peptides: A Worrying Phenomenon.
作者信息
Fleitas Osmel, Franco Octávio L
机构信息
Programa de Pós-Graduação em Patologia Molecular, Faculdade de Medicina, Universidade de BrasíliaBrasília, Brazil; Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de BrasíliaBrasília, Brazil.
Programa de Pós-Graduação em Patologia Molecular, Faculdade de Medicina, Universidade de BrasíliaBrasília, Brazil; Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de BrasíliaBrasília, Brazil; Programa de Pós-Graduação em Biotecnologia, S-Inova Biotech,Universidade Católica Dom BoscoCampo Grande, Brazil.
出版信息
Front Microbiol. 2016 Mar 24;7:381. doi: 10.3389/fmicb.2016.00381. eCollection 2016.
Bacterial resistance to conventional antibiotics has reached alarming levels, threatening to return to the pre-antibiotic era. Therefore, the search for new antimicrobial compounds that overcome the resistance phenomenon has become a priority. Antimicrobial peptides (AMPs) appear as one of the most promising antibiotic medicines. However, in recent years several AMP-resistance mechanisms have been described. Moreover, the AMP-resistance phenomenon has become more complex due to its association with cross-resistance toward AMP effectors of the host innate immune system. In this context, the use of AMPs as a therapeutic option could be potentially hazardous, since bacteria could develop resistance toward our innate immune system. Here, we review the findings of major studies that deal with the AMP cross-resistance phenomenon.
细菌对传统抗生素的耐药性已达到惊人程度，有使我们重回抗生素出现之前时代的危险。因此，寻找能够克服耐药现象的新型抗菌化合物已成为当务之急。抗菌肽（AMPs）似乎是最有前景的抗生素药物之一。然而，近年来已发现了几种抗菌肽耐药机制。此外，由于抗菌肽耐药现象与宿主先天免疫系统的效应器存在交叉耐药性，该现象变得更加复杂。在这种情况下，将抗菌肽用作治疗选择可能具有潜在危险性，因为细菌可能会对我们的先天免疫系统产生耐药性。在此，我们综述了有关抗菌肽交叉耐药现象的主要研究结果。
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