再生障碍性贫血患者侵袭性真菌感染的当前应对策略：力强而器不利，一例病例报告及文献综述
Current strategies against invasive fungal infections in patients with aplastic anemia, strong power and weak weapon, a case report and review of literature.
作者信息
Zekavat Omid Reza, Amanati Ali, Saleh Fazl, Abdolkarimi Babak, Fathpour Gholamreza, Badiee Parisa, Geramizadeh Bita
机构信息
Hematology Research Center, Namazi Hospital, Karimkhan Zand St., Shiraz 7193711351, Iran; Department of Pediatric Oncology, Amir Oncology Hospital, Farhang Shahr, Shiraz 7187915998, Iran.
Professor Alborzi Clinical Microbiology Research Center, Namazi Hospital, Karimkhan Zand St., Shiraz 7193711351, Iran; Department of Pediatric Infectious Diseases, Namazi Hospital, Karimkhan Zand St., Shiraz 7193711351, Iran.
出版信息
Med Mycol Case Rep. 2016 Mar 8;11:16-20. doi: 10.1016/j.mmcr.2016.03.003. eCollection 2016 Mar.
We report an 18 year old boy with Aplastic anemia complicated by serious fungal rhinosinusitis. Despite prompt treatment and early repeated surgical debridements, he died after about more than 6 weeks of hard challenges with fungal infections. Current strategies against invasive fungal infections (IFIs) in patients with Aplastic anemia may be inadequate for the management of serious complications. Antifungal prophylaxis is highly recommended in pre-transplant period for severe form of Aplastic anemia.
我们报告了一名18岁患有再生障碍性贫血并并发严重真菌性鼻-鼻窦炎的男孩。尽管进行了及时治疗和早期反复手术清创，但在与真菌感染进行了约6周多的艰难抗争后，他还是去世了。目前针对再生障碍性贫血患者侵袭性真菌感染（IFI）的策略可能不足以应对严重并发症的管理。对于重型再生障碍性贫血患者，强烈建议在移植前期进行抗真菌预防。
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