秀丽隐杆线虫中的程序性细胞死亡与细胞尸体清除
Programmed cell death and clearance of cell corpses in Caenorhabditis elegans.
作者信息
Wang Xiaochen, Yang Chonglin
机构信息
National Institute of Biological Sciences, No. 7 Science Park Road, Zhongguancun Life Science Park, Beijing, 102206, China.
State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, No. 1 West Beichen Road, Chaoyang District, Beijing, 100101, China.
出版信息
Cell Mol Life Sci. 2016 Jun;73(11-12):2221-36. doi: 10.1007/s00018-016-2196-z. Epub 2016 Apr 5.
Programmed cell death is critical to the development of diverse animal species from C. elegans to humans. In C. elegans, the cell death program has three genetically distinguishable phases. During the cell suicide phase, the core cell death machinery is activated through a protein interaction cascade. This activates the caspase CED-3, which promotes numerous pro-apoptotic activities including DNA degradation and exposure of the phosphatidylserine "eat me" signal on the cell corpse surface. Specification of the cell death fate involves transcriptional activation of the cell death initiator EGL-1 or the caspase CED-3 by coordinated actions of specific transcription factors in distinct cell types. In the cell corpse clearance stage, recognition of cell corpses by phagocytes triggers several signaling pathways to induce phagocytosis of apoptotic cell corpses. Cell corpse-enclosing phagosomes ultimately fuse with lysosomes for digestion of phagosomal contents. This article summarizes our current knowledge about programmed cell death and clearance of cell corpses in C. elegans.
程序性细胞死亡对于从秀丽隐杆线虫到人类等多种动物物种的发育至关重要。在秀丽隐杆线虫中,细胞死亡程序有三个基因可区分的阶段。在细胞自杀阶段,核心细胞死亡机制通过蛋白质相互作用级联被激活。这激活了半胱天冬酶CED - 3,其促进多种促凋亡活动,包括DNA降解以及在细胞尸体表面暴露磷脂酰丝氨酸“吃我”信号。细胞死亡命运的指定涉及通过不同细胞类型中特定转录因子的协同作用对细胞死亡起始因子EGL - 1或半胱天冬酶CED - 3进行转录激活。在细胞尸体清除阶段,吞噬细胞对细胞尸体的识别触发了几条信号通路,以诱导对凋亡细胞尸体的吞噬作用。包裹细胞尸体的吞噬体最终与溶酶体融合,用于消化吞噬体内容物。本文总结了我们目前关于秀丽隐杆线虫中程序性细胞死亡和细胞尸体清除的知识。